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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Functional interaction of erythropoietin and stem cell factor receptors is essential for erythroid colony formation
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Functional interaction of erythropoietin and stem cell factor receptors is essential for erythroid colony formation

机译:促红细胞生成素与干细胞因子受体的功能相互作用对于红系集落的形成至关重要

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摘要

Production of mature erythrocytes requires multiple growth factors, but we do not know how their actions are coordinated. Here we show that erythroid progenitors from erythropoietin receptor (Epo-R)~- /- fetal livers, infected in vitro with a retrovirus expressing the wild-type Epo-R, require addition of both Epo and stem cell factor (SCF) to form colony-forming unit erythroid (CFU-E) colonies. Thus, a functional interaction between KIT and the Epo-R, similar to what we reported in cultured cells, is essential for the function of CFU-E progenitors.
机译:成熟红细胞的产生需要多种生长因子,但是我们不知道它们的作用如何协调。在这里,我们显示来自促红细胞生成素受体(Epo-R)〜-/-胎儿肝脏的类红细胞祖细胞在体外感染了表达野生型Epo-R的逆转录病毒,需要同时添加Epo和干细胞因子(SCF)才能形成菌落形成单位红系(CFU-E)菌落。因此,与我们在培养细胞中报道的相似,KIT和Epo-R之间的功能相互作用对于CFU-E祖细胞的功能至关重要。

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