Requirement for an initial signal from the membrane-proximal region of the interleukin 2 receptor γ_c chain for Janus kinase activation leading to T cell proliferation

Brad H. Nelson; Bryan C. McIntosh; Lori L. Rosencrans

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Requirement for an initial signal from the membrane-proximal region of the interleukin 2 receptor γ_c chain for Janus kinase activation leading to T cell proliferation

机译：来自白细胞介素2受体γ_c链膜近端区域的初始信号对Janus激酶激活导致T细胞增殖的要求

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The interleukin 2 receptor (IL-2R) generates proliferative signals in T lymphocytes by ligand-induced heterodimerization of two chains, IL-2Rβ and γ_c, which associate with the tyrosine kinases Jak1 and Jak3, respec- tively. Genetic and molecular studies have demonstrated that Jak3 is essential for mitogenic signaling by the γ_c chain; because it is also the only molecule known to associate with γ_c, we speculated that Jak3 might be sufficient for signaling by this chain.

机译：白细胞介素2受体（IL-2R）通过配体诱导的两条链IL-2Rβ和γ_c分别与酪氨酸激酶Jak1和Jak3缔合，在T淋巴细胞中产生增殖信号。遗传和分子研究表明，Jak3对于γ_c链的促有丝分裂信号至关重要。因为它也是已知与γ_c缔合的唯一分子，我们推测Jak3可能足以通过该链进行信号传导。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第5期|p.1878-1883|共6页
作者
Brad H. Nelson; Bryan C. McIntosh; Lori L. Rosencrans;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. REQUIREMENT FOR AN INITIAL SIGNAL FROM THE MEMBRANE-PROXIMAL REGION OF THE INTERLEUKIN 2 RECEPTOR GAMMA(C) CHAIN FOR JANUS KINASE ACTIVATION LEADING TO T CELL PROLIFERATION [J] . Nelson BH., Rosencrans LL., Greenberg PD., Proceedings of the National Academy of Sciences of the United States of America . 1997,第5期

机译：从白细胞介素2受体GAMMA（C）链的膜近端区域启动J激酶激活导致T细胞增殖的初始信号要求
2. A membrane-proximal region of the interleukin-2 receptor gamma c chain sufficient for Jak kinase activation and induction of proliferation in T cells. [J] . B H Nelson, J D Lord, P D Greenberg Molecular and Cellular Biology . 1996,第1期

机译：白介素2受体γc链的膜近端区域足以激活Jak激酶并诱导T细胞中的增殖。
3. Structural requirements of the interleukin-6 signal transducer gp130 for its interaction with Janus kinase 1: the receptor is crucial for kinase activation [J] . Haan C, Heinrich PC, Behrmann I The Biochemical Journal . 2002,第1期

机译：白细胞介素6信号转导子gp130与Janus激酶1相互作用的结构要求：受体对于激酶激活至关重要
4. Activation of Androgen Receptor in Prostate Cancer: Role of Protein Kinase A and Extracellular Signal-regulated Kinases [C] . Yehia Daaka, Elizabeth Kasbohm, Charles Yowel International Symposium on Hormonal Carcinogenesis . 2005

机译：前列腺癌中雄激素受体的激活 - 蛋白激酶A和细胞外信号调节激酶的作用
5. The multi-targeted receptor tyrosine kinase inhibitor, linifanib (ABT-869), induces apoptosis and inhibits proliferation of leukemia cells through phosphoinositide-3 kinase (PI3K)/AKT-dependent signaling pathways. [D] . Hernandez, Jenny Elizabeth. 2010

机译：多靶点受体酪氨酸激酶抑制剂利尼法尼（ABT-869）通过磷酸肌醇3激酶（PI3K）/ AKT依赖性信号传导途径诱导凋亡并抑制白血病细胞的增殖。
6. Requirement for an initial signal from the membrane-proximal region of the interleukin 2 receptor γc chain for Janus kinase activation leading to T cell proliferation [O] . Brad H. Nelson, Bryan C. McIntosh, Lori L. Rosencrans, 1997

机译：从白细胞介素2受体γc链的膜近端区域发出的初始信号对Janus激酶激活导致T细胞增殖的要求
7. Requirement for an initial signal from the membrane-proximal region of the interleukin 2 receptor c chain for Janus kinase activation leading to T cell proliferation [O] . B. H. Nelson, B. C. McIntosh, L. L. Rosencrans, 1997

机译：从白细胞介素2受体C链的膜 - 近端区域的初始信号的要求导致T细胞增殖的Janus激酶活化

Requirement for an initial signal from the membrane-proximal region of the interleukin 2 receptor γ_c chain for Janus kinase activation leading to T cell proliferation

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