...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >PREVENTION OF EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS BY TARGETING NITRIC OXIDE AND PEROXYNITRITE - IMPLICATIONS FOR THE TREATMENT OF MULTIPLE SCLEROSIS
【24h】

PREVENTION OF EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS BY TARGETING NITRIC OXIDE AND PEROXYNITRITE - IMPLICATIONS FOR THE TREATMENT OF MULTIPLE SCLEROSIS

机译：靶向一氧化氮和过氧亚硝酸盐预防实验性过敏性脑膜炎-对多发性硬化症的治疗意义。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In this study we provide further evidence associating activated cells of the monocyte lineage with the lesions of multiple sclerosis (MS). Using a combination of immunohistochemistry and reverse transcriptase-dependent in situ polymerase chain reaction analysis, we have identified monocytes expressing inducible nitric oxide synthase (iNOS) to be prevalent in the plaque areas of post mortem brain tissue from patients with MS. In addition, we have obtained evidence of the nitration of tyrosine residues in brain areas local to accumulations of iNOS-positive cells. In parallel studies ne have assessed the effects of inhibitors of INOS induction, as well as scavengers of nitric oxide and peroxynitrite in the experimental allergic encephalomyelitis model, Significant therapeutic effects were seen with the inhibitor of iNOS induction, tricyclodecan-9-xyl-xanthogenate, a nitric oxide a scavenger, 2-phenyl-4,4,5,5'-tetramethylimidazoline-1-oxyl-3-oxide, and a peroxynitrite scavenger, uric acid, In particular, treatment with high doses of uric acid virtually prevented clinical symptoms of the disease. Together with our demonstration of the presence of activated macrophages expressing high levels of iNOS and evidence of peroxynitrite formation in brain tissue from patients with MS, these findings are of importance in the development of approaches to treat this disease. [References: 33]
机译：在这项研究中，我们提供了进一步的证据证明单核细胞谱系的活化细胞与多发性硬化症（MS）的损伤有关。通过结合使用免疫组织化学和依赖逆转录酶的原位聚合酶链反应分析，我们确定了表达诱导型一氧化氮合酶（iNOS）的单核细胞在MS患者的死后脑组织的斑块区域盛行。此外，我们已经获得了iNOS阳性细胞积累局部区域的酪氨酸残基硝化的证据。在平行研究中，已经评估了INOS诱导抑制剂以及一氧化氮和过氧亚硝酸盐清除剂在实验性变应性脑脊髓炎模型中的作用。iNOS诱导抑制剂tricyclodecan-9-xyl-xanthogenate，一氧化氮，清除剂，2-苯基-4,4,5,5'-四甲基咪唑啉-1-氧基-3-氧化物和过氧亚硝酸盐清除剂尿酸，尤其是高剂量尿酸治疗实际上阻止了临床该疾病的症状。结合我们对表达高水平iNOS的活化巨噬细胞的存在以及MS患者脑组织中过亚硝酸盐形成的证据的佐证，这些发现对开发这种疾病的方法具有重要意义。 [参考：33]

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号