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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >HYPERRESPONSIVE FEBRILE REACTIONS TO INTERLEUKIN (IL) 1-ALPHA AND IL-1-BETA, AND ALTERED BRAIN CYTOKINE MRNA AND SERUM CYTOKINE LEVELS, IN IL-1-BETA-DEFICIENT MICE
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HYPERRESPONSIVE FEBRILE REACTIONS TO INTERLEUKIN (IL) 1-ALPHA AND IL-1-BETA, AND ALTERED BRAIN CYTOKINE MRNA AND SERUM CYTOKINE LEVELS, IN IL-1-BETA-DEFICIENT MICE

机译：IL-1-β缺乏症小鼠对白细胞介素（IL）1-ALPHA和IL-1 -BET的超反应性反应，以及改变的脑细胞因子和血清细胞因子水平

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摘要

IL-1 beta is an endogenous pyrogen that is induced during systemic lipopolysaccharide (LPS) or IL-1-induced fever, We have examined the fever and cytokine responses following i.p. injection of IL-1 agonists, IL-1 alpha and IL-1 beta, and compared these with response to LPS (i.p.) in wild-type and IL-1 beta-deficient mice, The IL-1 beta deficient mice appear to have elevated body temperature but exhibit a normal circadian temperature cycle. Exogenously injected IL-1 beta, IL-1 alpha, or LPS induced hyperresponsive fevers in the IL-1 beta-deficient mice, We also observed phenotypic differences between wild-type and IL-1 beta-deficient mice in hypothalamic basal mRNA levels for IL-1 alpha and IL-6, but not for IL-1 beta-converting enzyme or IL-1 receptor type I or type II, The IL-1 alpha mRNA levels were down-regulated, whereas the IL-6 mRNA levels were up-regulated in the hypothalamus of IL-1 beta-deficient mice as compared with wild-type mice, The IL-1 beta-deficient mice also responded to LPS challenge with significantly higher serum corticosterone and with lower serum tumor necrosis factor type alpha levels than the wild-type mice. The data suggest that, in the redundant cascade of proinflammatory cytokines, IL-1 beta plays an important but not obligatory role in fever induction by LPS or IL-1 alpha, as well as in the induction of serum tumor necrosis factor type alpha and corticosterone responses either by LPS or by IL-1 alpha or IL-1 beta. [References: 16]
机译：IL-1β是一种内源性热原，在全身性脂多糖（LPS）或IL-1引起的发烧过程中被诱导。我们检查了i.p.之后的发烧和细胞因子反应。注射IL-1激动剂，IL-1 alpha和IL-1 beta，并将其与野生型和IL-1 beta缺陷小鼠对LPS（ip）的反应进行比较，IL-1 beta缺陷小鼠似乎具有体温升高，但昼夜节律正常。外源注射IL-1 beta，IL-1 alpha或LPS引起IL-1 beta缺陷小鼠的高反应性发烧，我们还观察到野生型和IL-1 beta缺陷小鼠之间下丘脑基底mRNA水平的表型差异IL-1 alpha和IL-6，但不是针对IL-1 beta转换酶或I-1型或II型IL-1受体，IL-1 alpha mRNA水平下调，而IL-6 mRNA水平下调与野生型小鼠相比，IL-1β缺陷型小鼠的下丘脑中表达上调，IL-1β缺陷型小鼠对LPS刺激也有明显更高的血清皮质酮和更低的血清肿瘤坏死因子α水平比野生型小鼠数据表明，在多余的促炎细胞因子级联反应中，IL-1β在LPS或IL-1α引起的发热诱导以及血清肿瘤坏死因子类型α和皮质酮的诱导中起着重要但不是强制性的作用通过LPS或IL-1 alpha或IL-1 beta做出反应。 [参考：16]

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