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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >MICROSATELLITE DIVERSITY AND THE DEMOGRAPHIC HISTORY OF MODERN HUMANS
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MICROSATELLITE DIVERSITY AND THE DEMOGRAPHIC HISTORY OF MODERN HUMANS

机译：微卫星多样性与现代人类的人口历史

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Wt have examined differences in diversity at 68 microsatellite loci among human population samples from three major continental groups to evaluate the hypothesis of greater African diversity in this rapidly evolving class of loci, Application of a statistical test that assumes equal mutation rates at all loci fails to demonstrate differences in microsatellite diversity, while a randomization test that does not make this assumption finds that Africans have significantly greater microsatellite diversity (P < 10(-8)) than do Asians and Europeans. Greater African diversity is most apparent at loci with smaller overall variance in allele size, suggesting that the record of population history has been erased at repeat loci with higher mutation rates. A power analysis shows that only 35-40 microsatellites are needed to establish this difference statistically, demonstrating the considerable evolutionary information contained in these systems. On average, African populations have approximate to 20% greater microsatellite diversity than do Asian and European populations. A comparison of continental diversity differences in microsatellites and mtDNA sequences suggests earlier demographic expansion of the ancestors of Africans. [References: 36]
机译：Wt已检查了来自三个主要大陆组的人群样本中68个微卫星基因座的多样性差异，以评估这一迅速发展的基因座类别中更大非洲多样性的假说。采用统计检验假设所有基因座的突变率均未达到证明微卫星多样性的差异，而没有做出此假设的随机检验发现，非洲人比亚洲人和欧洲人具有更大的微卫星多样性（P <10（-8））。更大的非洲多样性在等位基因大小总体差异较小的基因座上最为明显，这表明在具有较高突变率的重复基因座处，种群历史记录已被删除。功率分析表明，仅需要35-40个微卫星就可以从统计学上确定这种差异，从而证明了这些系统中包含的大量进化信息。平均而言，非洲人口的微卫星多样性比亚洲和欧洲人口高大约20％。微卫星和mtDNA序列中大陆多样性差异的比较表明，非洲人祖先的人口增长较早。 [参考：36]

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