Peptide-specific killing of antigen-presenting cells by a recombinant antibody-toxin fusion protein targeted to major histocompatibility complex/peptide class I complexes with T cell receptor-like specificity

Yoram Reiter; Angelina Di Carlo; Lars Fugger

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Peptide-specific killing of antigen-presenting cells by a recombinant antibody-toxin fusion protein targeted to major histocompatibility complex/peptide class I complexes with T cell receptor-like specificity

机译：通过靶向主要组织相容性复合物/ I类肽复合物的重组抗体-毒素融合蛋白以T细胞受体样特异性靶向杀死抗原呈递细胞

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Specificity in the immune system is dictated and regulated by specific recognition of peptide/major histo- compatibility complex (MHC) complexes by the T cell recep- tor. Such peptide/MHC complexes are a desirable target for novel approaches in immunotherapy because of their highly restricted fine specificity. Recently, phage display was used to isolate an antibody that has T cell receptor-like specificity. It recognizes mouse MHC class I H-2K~k molecules complexed with a H-2K~k-restricted influenza virus-derived hemaggluti- nin peptide (Ha) but does not bind to class I H-2K~k alone, peptide alone, or H-2K~k complexed with other peptides.

机译：免疫系统的特异性是由T细胞受体特异性识别肽/主要组织相容性复合物（MHC）复合物来决定和调节的。此类肽/ MHC复合物由于其高度受限的精细特异性而成为免疫疗法新方法的理想靶标。最近，噬菌体展示被用于分离具有T细胞受体样特异性的抗体。它可以识别与H-2K〜k限制性流感病毒衍生的血凝素肽（Ha）复合的小鼠MHC I H-2K〜k分子，但不能单独与I H-2K〜k类结合，也不能与肽结合，或H-2K〜k与其他肽复合。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第9期|p.4631-4636|共6页
作者
Yoram Reiter; Angelina Di Carlo; Lars Fugger;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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2. CD40 Ligand-activated, antigen-specific B cells are comparable to mature dendritic cells in presenting protein antigens and major histocompatibility complex class I- and class II-binding peptides. [J] . Ahmadi T, Flies A, Efebera Y, Immunology: An Official Journal of the British Society for Immunology . 2008,第1期

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6. Peptide-specific killing of antigen-presenting cells by a recombinant antibody–toxin fusion protein targeted to major histocompatibility complex/peptide class I complexes with T cell receptor-like specificity [O] . Yoram Reiter, Angelina Di Carlo, Lars Fugger, 1997

机译：通过靶向主要组织相容性复合物/ I类肽复合物的重组抗体-毒素融合蛋白以T细胞受体样特异性靶向杀伤抗原呈递细胞
7. Peptide-specific killing of antigen-presenting cells by a recombinant antibody-toxin fusion protein targeted to major histocampatibility complex/peptide class I complexes with T cell receptor-like specificity [O] . REITER Y, A. DI CARLO, FUGGER L, 1997

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8. Role of the Major Histocompatibility Complex in T Cell Activation of B Cell Subpopulations, Lyb-5(+) and Lyb-5(-) B Cell Subpopulations Differ in Their Requirement for Major Histocompatibility Complex-Restricted T Cell Recognition [R] . Singer, A., Morrissey, P. J., Hathcock, K. S., 1981

机译：主要组织相容性复合物在B细胞亚群，Lyb-5（+）和Lyb-5（ - ）B细胞亚群的T细胞活化中的作用不同于它们对主要组织相容性复杂限制性T细胞识别的要求

Peptide-specific killing of antigen-presenting cells by a recombinant antibody-toxin fusion protein targeted to major histocompatibility complex/peptide class I complexes with T cell receptor-like specificity

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