The bovine papillomavirus E6 oncoprotein interacts with paxillin and disrupts the actin cytoskeleton

Xiao Tong; Peter M. Howley

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The bovine papillomavirus E6 oncoprotein interacts with paxillin and disrupts the actin cytoskeleton

机译：牛乳头瘤病毒E6癌蛋白与Paxillin相互作用并破坏肌动蛋白的细胞骨架

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The E6 oncoprotein of bovine papillomavirus type 1 (BPV-1) has been shown to transform cells through a p53-independent pathway, but its transforming mechanism is unknown. Here we demonstrate in vitro and in vivo interactions between BPV-1 E6 and the focal adhesion protein paxillin. The ability of BPV-1 E6 to complex with paxillin correlated with its ability to transform; E6 mutant proteins impaired in their transformation function also were impaired in their abilities to bind paxillin.

机译：牛乳头瘤病毒1型（BPV-1）的E6癌蛋白已显示可通过不依赖p53的途径转化细胞，但其转化机理尚不清楚。在这里，我们证明了BPV-1 E6与黏着斑蛋白paxillin之间的体外和体内相互作用。 BPV-1 E6与Paxillin复合的能力与其转化能力有关； E6突变蛋白的转化功能受到损害，其结合paxillin的能力也受到损害。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第9期|p.4412-4417|共6页
作者
Xiao Tong; Peter M. Howley;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Human papillomavirus type 16 E6 and E7 oncoproteins interact with the nuclear p53-binding protein 1 in an in vitro reconstructed 3D epithelium: new insights for the virus-induced DNA damage response [J] . Diletta Francesca Squarzanti, Rita Sorrentino, Manuela Miriam Landini, Virology Journal . 2018,第1期

机译：人乳头瘤病毒16型E6和E7癌蛋白在体外重建的3D上皮细胞中与核p53结合蛋白1相互作用：病毒诱导的DNA损伤反应的新见解
2. The E7 oncoprotein of human papillomavirus type 16 interacts with F-actin in vitro and in vivo. [J] . Rey O, Lee S, Baluda MA, Virology . 2000,第2期

机译：16型人乳头瘤病毒的E7癌蛋白在体内外均与F-肌动蛋白相互作用。
3. Bovine papillomavirus E5 oncoprotein expression and its association with an interactor network in aggresome-autophagy pathway [J] . Roperto Sante, Russo Valeria, De Falco Francesca, Veterinary Microbiology . 2019,第期

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4. Disruption and Re-polymerization Kinetics of f-actin Cytoskeleton in Bone Cells Subjected to Dynamic Mechanical Stimulus [C] . R.S.A. Nesbitt, J. Macione, M. Eschbach, World congress on medical physics and biomedical engineering;International congress of the IUPESM . 2011

机译：f-肌动蛋白细胞骨架在动态机械刺激下的破坏和再聚合动力学
5. The tumor suppressor protein p53 and the antagonizing oncoprotein E6 from human papillomavirus type 16 [D] . Malecka, Kimberly Ann 2010

机译：人类乳头瘤病毒16型的抑癌蛋白p53和拮抗癌蛋白E6
6. The bovine papillomavirus E6 oncoprotein interacts with paxillin and disrupts the actin cytoskeleton [O] . Xiao Tong, Peter M. Howley 1997

机译：牛乳头瘤病毒E6癌蛋白与Paxillin相互作用并破坏肌动蛋白的细胞骨架
7. Association of Bovine Papillomavirus Type 1 E6 oncoprotein with the focal adhesion protein paxillin through a conserved protein interaction motif [O] . Scott B Vande Pol, Michael C Brown, Christopher E Turner 1998

机译：通过保守的蛋白质相互作用基序，牛乳头瘤病毒1 e6癌蛋白与局灶性粘附蛋白帕西林

The bovine papillomavirus E6 oncoprotein interacts with paxillin and disrupts the actin cytoskeleton

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