Structural basis of DNA bending and oriented heterodimer binding by the basic leucine zipper domains of Fos and Jun

David A. Leonard; Nirmala Rajaram; Tom K. Kerppola

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Structural basis of DNA bending and oriented heterodimer binding by the basic leucine zipper domains of Fos and Jun

机译：Fos和Jun的基本亮氨酸拉链结构域的DNA弯曲和定向异二聚体结合的结构基础

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Interactions among transcription factors that bind to separate sequence elements require bending of the intervening DNA and juxtaposition of interacting molecular surfaces in an appropriate orientation. Here, we examine the effects of single amino acid substitutions adjacent to the basic regions of Fos and Jun as well as changes in sequences flanking the AP-1 site on DNA bending. Substitution of charged amino acid residues at positions adjacent to the basic DNA-binding domains of Fos and Jun altered DNA bending.

机译：与单独的序列元件结合的转录因子之间的相互作用需要弯曲插入的DNA，并在适当的方向上并置相互作用的分子表面。在这里，我们检查了与Fos和Jun的基本区域相邻的单个氨基酸取代的影响，以及DNA弯曲时位于AP-1位点侧翼的序列的变化。在与Fos和Jun的基本DNA结合结构域相邻的位置取代带电氨基酸残基改变了DNA弯曲。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第10期|p.4913-4918|共6页
作者
David A. Leonard; Nirmala Rajaram; Tom K. Kerppola;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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专利

1. Addition of positively charged tripeptide to N-terminus of the Fos basic region leucine zipper domain: Implications on DNA bending, affinity, and specificity [J] . Mahmoudi Tokameh, Sarkar Bibudhendra Biopolymers: Original Research on Biomolecules and Biomolecular Assemblies . 1999,第3期

机译：在Fos碱性区域亮氨酸拉链结构域的N末端添加带正电荷的三肽：对DNA弯曲，亲和力和特异性的影响
2. DNA-binding specificity of the PAR basic leucine zipper protein VBP partially overlaps those of the C/EBP and CREB/ATF families and is influenced by domains that flank the core basic region. [J] . N B Haas, C A Cantwell, P F Johnson, Molecular and Cellular Biology . 1995,第4期

机译：PAR基本亮氨酸拉链蛋白VBP的DNA结合特异性与C / EBP和CREB / ATF家族的DNA结合特异性部分重叠，并受位于核心碱性区域侧翼的域的影响。
3. Dissecting the role of leucine zippers in the binding of bZIP domains of Jun transcription factor to DNA. [J] . Seldeen KL, McDonald CB, Deegan BJ, Biochemical and Biophysical Research Communications . 2010,第4期

机译：剖析亮氨酸拉链在Jun转录因子的bZIP域与DNA结合中的作用。
4. BINDING AND PROTECTION OF DNA BY A NOVEL PEPTIDE DERIVED FROM THE DNA-BINDING REGION OF THE FOS-JUN COMPLEX [C] . Y. Uesugi, S. Ogata, M. Tanihara International symposium on controlled release of bioactive materials;Consumer diversified products conference . 2001

机译：FOS-JUN复合物的DNA结合区衍生的新型肽对DNA的结合和保护
5. Investigating the Aggregation of the Basic Leucine Zipper (bZIP) Domain of Activating Transcription Factor 5 (ATF5). [D] . Ciaccio, Natalie A. 2010

机译：研究激活转录因子5（ATF5）的基本亮氨酸拉链（bZIP）域的聚集。
6. Structural basis of DNA bending and oriented heterodimer binding by the basic leucine zipper domains of Fos and Jun [O] . David A. Leonard, Nirmala Rajaram, Tom K. Kerppola 1997

机译：Fos和Jun基本亮氨酸拉链结构域的DNA弯曲和定向异源二聚体结合的结构基础
7. Expression and purification of the leucine zipper and DNA-binding domains of Fos and Jun: both Fos and Jun contact DNA directly. [O] . Abate, C, Luk, D, Gentz, R, 1990

机译：Fos和Jun的亮氨酸拉链和DNA结合域的表达和纯化：Fos和Jun都直接接触DNA。

Structural basis of DNA bending and oriented heterodimer binding by the basic leucine zipper domains of Fos and Jun

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