DAD1, the defender against apoptotic cell death, is a subunit of the mammalian oligosaccharyltransferase

Daniel J. Kelleher; Reid Gilmore

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DAD1, the defender against apoptotic cell death, is a subunit of the mammalian oligosaccharyltransferase

机译：DAD1是凋亡细胞死亡的防御者，是哺乳动物寡糖基转移酶的一个亚基

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DAD1, the defender against apoptotic cell death, was initially identified as a negative regulator of programmed cell death in the BHK21-derived tsBN7 cell line. Of interest, the 12.5-kDa DAD1 protein is 40/100 identical in sequence to Ost2p, the 16-kDa subunit of the yeast oligosac- charyltransferase (OST). Although the latter observation suggests that DAD1 may be a mammalian OST subunit, biochemical evidence to support this hypothesis has not been reported. Previously, we showed that canine OST activity is associated with an oligomeric complex of ribophorin I, ribo- phorin II, and OST48.

机译：DAD1是凋亡细胞死亡的防御者，最初被确定为BHK21衍生的tsBN7细胞系中程序性细胞死亡的负调节剂。有趣的是，12.5 kDa DAD1蛋白的序列与酵母寡糖基转移酶（OST）的16 kDa亚基Ost2p在序列上具有40/100相同。尽管后者的观察结果提示DAD1可能是哺乳动物OST亚基，但尚无支持该假说的生化证据。以前，我们表明犬的OST活性与核糖蛋白I，核糖蛋白II和OST48的寡聚复合物有关。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第10期|p.4994-4999|共6页
作者
Daniel J. Kelleher; Reid Gilmore;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. A homologue of the defender against the apoptotic death gene (dad1) in UV-exposed Chlamydomonas cells is downregulated with the onset of programmed cell death [J] . Swati Moharkar, Jacinta S DSouza, Basuthkar J Rao Journal of Biosciences . 2007,第2期

机译：随着程序性细胞死亡的发生，下调了暴露于紫外线的衣原体细胞中针对凋亡死亡基因（dad1）的防御者的同源物
2. A homologue of the defender against the apoptotic death gene (dad1) in UV-exposed Chlamydomonas cells is downregulated with the onset of programmed cell death [J] . Swati Moharikar, Jacinta S D’souza, Basuthkar J Rao Journal of Biosciences . 2007,第2期

机译：随着程序性细胞死亡的发生，下调了暴露于紫外线的衣原体细胞中针对凋亡死亡基因（dad1）的防御者的同源物
3. A homologue of the defender against the apoptotic death gene (dad1) in UV-exposed Chlamydomonas cells is downregulated with the onset of programmed cell death [J] . Basuthkar J Rao1, Jacinta S Da€?souza, Swati Moharikar Journal of biosciences . 2007,第2期

机译：随着程序性细胞死亡的发生，下调了暴露于紫外线的衣原体细胞中针对凋亡死亡基因（dad1）的防御者的同源物
4. Activation of apoptotic cell death in human myeloid leukemia cells by RNS: A novel antitumor approach using resistive barrier plasma [C] . Anderson Heather, Gonzales Xavier, Valdez Samantha, 2013 Abstracts IEEE International Conference on Plasma Science . 2013

机译：RNS激活人类髓样白血病细胞凋亡性细胞死亡：使用抵抗性屏障血浆的新型抗肿瘤方法
5. Inhibition of programmed cell death in mammalian cell culture using modified and multiple anti-apoptotic Bcl-2 proteins. [D] . Figueroa, Bruno, Jr. 2002

机译：使用修饰的和多种抗凋亡Bcl-2蛋白在哺乳动物细胞培养中抑制程序性细胞死亡。
6. DAD1 the defender against apoptotic cell death is a subunit of the mammalian oligosaccharyltransferase [O] . Daniel J. Kelleher, Reid Gilmore 1997

机译：DAD1是凋亡细胞死亡的防御者是哺乳动物寡糖基转移酶的一个亚基
7. The oligosaccharyltransferase subunits OST48, DAD1 and KCP2 function as ubiquitous and selective modulators of mammalian N-glycosylation [O] . Roboti, Peristera, High, Stephen 2012

机译：寡糖基转移酶亚基OsT48，DaD1和KCp2作为哺乳动物N-糖基化的普遍存在和选择性调节剂起作用。
8. Intracellular Survival of Campylobacter jejuni in Human Monocytic Cells and Induction of Apoptotic Death by Cytholethal Distending Toxin [R] . Hickey, T. E. , Majam, G. , Guerry, P. 2005

机译：人单核细胞空肠弯曲杆菌细胞内存活及Cytholethal Distending Toxin诱导细胞凋亡

DAD1, the defender against apoptotic cell death, is a subunit of the mammalian oligosaccharyltransferase

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