Sequence dependent hypermutation of the immunoglobulin heavy chain in cultured B cells

Mark Mu-Quan Lin; Minghua Zhu; Matthew D. Scharff

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Sequence dependent hypermutation of the immunoglobulin heavy chain in cultured B cells

机译：B细胞中免疫球蛋白重链的序列依赖性超突变

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The variable (V) regions of immunoglobulin heavy and light chains undergo high rates of somatic mutation during the immune response. Although point mutations ac- cumulate throughout the V regions and their immediate flanking sequences, analysis of large numbers of mutations that have arisen in vivo reveal that the triplet AGC appears to be most susceptible to mutation.

机译：免疫球蛋白重链和轻链的可变（V）区在免疫反应过程中经历高程度的体细胞突变。尽管点突变累积在整个V区及其直接侧翼序列中，但对体内大量突变的分析表明，三重态AGC似乎最容易突变。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第10期|p.5284-5289|共6页
作者
Mark Mu-Quan Lin; Minghua Zhu; Matthew D. Scharff;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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机译：免疫球蛋白重链3'调节区Super-Enhancer影响B1 B细胞的体细胞增强率
2. HBL-3 cell line, derived from precursor B-cell lymphoblastic leukemia, lacks somatic hypermutation of immunoglobulin heavy chain variable region genes. [J] . Hojo H, Sasaki Y, Nakamura N, Pediatric and developmental pathology: the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society . 2004,第3期

机译：源自前体B细胞淋巴细胞白血病的HBL-3细胞系缺乏免疫球蛋白重链可变区基因的体细胞超突变。
3. Intracellular Distribution of Immunoglobulin Heavy and Light Chains Within Tissue Cultured Cells of Human Lymphoid Origin Detected by Electron Microscopy [J] . Hideo Kamei, Ikuo Suzuki, Morinobu Takahashi, The journal of immunology . 1970,第4期

机译：电镜检测人淋巴来源的组织培养细胞内免疫球蛋白重链和轻链的细胞内分布
4. MECHANISMS OF IMMUNOGLOBULIN G (IgG) TRANSPORT ACROSS PRIMARY CULTURED RAT ALVEOLAR EPITHELIAL CELL MONOLAYERS [C] . T.E. Fandy, V.H.L. Lee, E.D. Crandall, International symposium on controlled release of bioactive materials;Consumer diversified products conference . 2001

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5. Pathways and consequences of antibody heavy chain rearrangement in B cells with a site-directed heavy chain transgene. [D] . Yunk, Lenka. 2009

机译：具有定点重链转基因的B细胞中抗体重链重排的途径和后果。
6. Sequence dependent hypermutation of the immunoglobulin heavy chain in cultured B cells [O] . Mark Mu-Quan Lin, Minghua Zhu, Matthew D. Scharff 1997

机译：培养的B细胞中免疫球蛋白重链的序列依赖性超突变
7. MicroRNA Expression, Chromosomal Alterations, and Immunoglobulin Variable Heavy Chain Hypermutations in Mantle Cell Lymphomas [O] . Alba Navarro, Sílvia Beà, Verónica Fernández, 2009

机译：Microrna表达，染色体改变和免疫球蛋白可变重链超乳链淋巴瘤

Sequence dependent hypermutation of the immunoglobulin heavy chain in cultured B cells

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