Transient aggregates in protein folding are easily mistaken for folding intermediates

Maria Silow; Mikael Oliveberg

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Transient aggregates in protein folding are easily mistaken for folding intermediates

机译：蛋白质折叠中的瞬时聚集体很容易被误认为是折叠中间体

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It has been questioned recently whether pop- ulated intermediates are important for the protein folding process or are artefacts trapped in nonproductive pathways. We report here that the rapidly formed intermediate of the spliceosomal protein U1A is an off-pathway artefact caused by transient aggregation of denatured protein under native con- ditions. Transient aggregates are easily mistaken for struc- tured monomers and could be a general problem in time- resolved folding studies.

机译：最近有人质疑，人口稠密的中间体对于蛋白质折叠过程是否重要，或者是非生产途径中捕获的假象。我们在这里报道，剪接体蛋白U1A的快速形成的中间体是在自然条件下由变性蛋白的瞬时聚集引起的偏离途径的假象。瞬态聚集体很容易被误认为是结构单体，并且可能是时间分辨折叠研究中的一个普遍问题。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第12期|p.6084-6086|共3页
作者
Maria Silow; Mikael Oliveberg;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Topology and sequence in the folding of a TIM barrel protein: Global analysis highlights partitioning between transient off-pathway and stable on-pathway folding intermediates in the complex folding mechanism of a (beta alpha)(8) barrel of unknown fu [J] . Forsyth WR, Bilsel O, Gu Z, Journal of Molecular Biology . 2007,第1期

机译：TIM桶蛋白折叠的拓扑结构和序列：全局分析突出了未知fu的（beta alpha）（8）桶的复杂折叠机制中瞬态途径和稳定途径折叠中间体之间的分配
2. Transient intermediates are populated in the folding pathways of single-domain two-state folding protein L [J] . Maity Hiranmay, Reddy Govardhan The Journal of Chemical Physics . 2018,第16期

机译：暂时中间体被填充在单域两级折叠蛋白L的折叠途径中
3. Protein topology affects the appearance of intermediates during the folding of proteins with a flavodoxin-like fold. [J] . Bollen YJ, van Mierlo CP Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena . 2005,第2a3期

机译：蛋白质拓扑结构会以类黄素毒素折叠形式影响蛋白质折叠过程中中间体的出现。
4. Transient laser spectroscopy of protein folding: detection and characterization of slow annealing processes [C] . Vinod Subramaniam, Univ. of Michigan, Ann Arbor, National Science Foundation (NSF) Forum on Optical Science and Engineering . 1995

机译：蛋白质折叠的瞬态激光光谱：缓慢退火过程的检测和表征
5. Transient intermediate units in protein folding. [D] . Hoang, Linh Duy. 2003

机译：蛋白质折叠中的瞬时中间单元。
6. Transient aggregates in protein folding are easily mistaken for folding intermediates [O] . Maria Silow, Mikael Oliveberg 1997

机译：蛋白质折叠中的瞬时聚集体很容易被误认为是折叠中间体
7. 2P102 Euilibrium intermediate and transient intermediate of src SH3 and its mutant(Proteins-stability, folding, and other physicochemical properties,Oral Presentations) [O] . Xianju Jin, Jinsong Li, Yoshitaka Matsumura, 2007

机译：2p102 euilibium中间体和src sh3的中间体和突变体（蛋白质 - 稳定性，折叠和其他物理化学性质，口腔呈现）
8. Folding of Aggregated Proteins to Functionally Active Form [R] . Swietnicki, W. 2006

机译：聚集蛋白质折叠成功能活性形式

Transient aggregates in protein folding are easily mistaken for folding intermediates

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