Mast cell tumor necrosis factor α production is regulated by MEK kinases

Tamotsu Ishizuka; Naohiro Terada; Par Gerwins

首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Mast cell tumor necrosis factor α production is regulated by MEK kinases

【24h】

Mast cell tumor necrosis factor α production is regulated by MEK kinases

机译：肥大细胞肿瘤坏死因子α的产生受MEK激酶调节

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Mast cells synthesize and secrete specific cytokines and chemokines which play an important role in allergic inflammation. Aggregation of the high-affinity Fc receptor (FcεRI) for immunoglobulin E (IgE) in MC/9 mouse mast cells stimulates the synthesis and secretion of tumor necrosis factor α (TNF-α). FcRI aggregation activates sev- eral sequential protein kinase pathways, leading to increased activity of extracellular signal-regulated kinases (ERKs), c-Jun amino-terminal kinases (JNKs), and the p38 mitogen- activated protein (MAP) kinase.

机译：肥大细胞合成并分泌在过敏性炎症中起重要作用的特定细胞因子和趋化因子。 MC / 9小鼠肥大细胞中免疫球蛋白E（IgE）的高亲和力Fc受体（FcεRI）的聚集刺激了肿瘤坏死因子α（TNF-α）的合成和分泌。 FcRI聚集激活了多个顺序蛋白激酶途径，从而导致细胞外信号调节激酶（ERK），c-Jun氨基末端激酶（JNKs）和p38促分裂原活化蛋白（MAP）激酶的活性增强。

著录项

来源
《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第12期|p.6358-6363|共6页
作者
Tamotsu Ishizuka; Naohiro Terada; Par Gerwins;
展开▼
作者单位

展开▼
收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词

相似文献

外文文献
中文文献
专利

1. Lansoprazole, a Proton Pump Inhibitor, Suppresses Production of Tumor Necrosis Factor-α and Interleukin-1β Induced by Lipopolysaccharide and Helicobacter Pylori Bacterial Components in Human Monocytic Cells via Inhibition of Activation of Nuclear Factor-κB and Extracellular Signal-Regulated Kinase [J] . Tetsuya Tanigawa, Toshio Watanabe, Kazuhide Higuchi, Journal of clinical biochemistry and nutrition. . 2009,第1期

机译：质子泵抑制剂Lansoprazole抑制人单核细胞中脂多糖和幽门螺杆菌细菌成分诱导的肿瘤坏死因子-α和白介素-1β的产生，通过抑制核因子-κB和细胞外信号调节的激酶的激活。
2. Lansoprazole, a Proton Pump Inhibitor, Suppresses Production of Tumor Necrosis Factor-alpha and Interleukin-1beta Induced by Lipopolysaccharide and Helicobacter Pylori Bacterial Components in Human Monocytic Cells via Inhibition of Activation of Nuclear Factor-kappaB and Extracellular Signal-Regulated Kinase. [J] . Tanigawa T, Watanabe T, Higuchi K, Journal of clinical biochemistry and nutrition. . 2009,第1期

机译：通过抑制核因子-κB和细胞外信号调节激酶的激活，兰替辛泵抑制剂，抑制人单核细胞中的脂多糖和幽门螺杆菌细菌组分的肿瘤坏死因子-α和白细胞介素-1β的产生。
3. Differential effects of p38- and extracellular signal-regulated kinase mitogen-activated protein kinase inhibitors on inducible nitric oxide synthase and tumor necrosis factor production in murine macrophages stimulated with Streptococcus pneumoniae. [J] . Monier RM, Orman KL, Meals EA, The Journal of Infectious Diseases . 2002,第7期

机译：p38和细胞外信号调节激酶促分裂原活化蛋白激酶抑制剂对肺炎链球菌刺激的小鼠巨噬细胞中诱导型一氧化氮合酶和肿瘤坏死因子产生的不同作用。
4. Protective Roles of Mast Cell-derived Tumor Necrosis Factor in Murine Malaria [C] . N. Watanabe, T. Kikuchi, Y. Iwakura, International Congress of Parasitology . 2006

机译：肥大细胞源性肿瘤坏死因子在鼠疟疾中的保护作用
5. Insulin-like growth factor-I in fibroproliferative acute respiratory distress syndrome: The molecular mechanisms of tumor necrosis factor regulated insulin-like growth factor-I production in macrophages. [D] . Krein, Peter M. 2003

机译：纤维增生性急性呼吸窘迫综合征中的胰岛素样生长因子-I：肿瘤坏死因子调节巨噬细胞中胰岛素样生长因子-I产生的分子机制。
6. Mast cell tumor necrosis factor α production is regulated by MEK kinases [O] . Tamotsu Ishizuka, Naohiro Terada, Pär Gerwins, 1997

机译：肥大细胞肿瘤坏死因子α的产生受MEK激酶的调节
7. Lansoprazole, a Proton Pump Inhibitor, Suppresses Production of Tumor Necrosis Factor-α and Interleukin-1β Induced by Lipopolysaccharide and Helicobacter Pylori Bacterial Components in Human Monocytic Cells via Inhibition of Activation of Nuclear Factor-κB and Extracellular Signal-Regulated Kinase [O] . Tanigawa, Tetsuya, Watanabe, Toshio, Higuchi, Kazuhide, 2009

机译：质子泵抑制剂Lansoprazole抑制人单核细胞中脂多糖和幽门螺杆菌细菌成分诱导的肿瘤坏死因子-α和白介素-1β的产生，通过抑制核因子-κB的活化和细胞外信号调节的激酶。

Mast cell tumor necrosis factor α production is regulated by MEK kinases

摘要

著录项

相似文献

相关主题

期刊订阅