A chemoattractant cytokine associated with granulomas in tuberculosis and silicosis

Gerard J. Nau; Patrick Guilfoile; Geoffrey L. Chupp

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A chemoattractant cytokine associated with granulomas in tuberculosis and silicosis

机译：与结核和矽肺肉芽肿相关的趋化性细胞因子

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Chronic inflammation and granuloma forma- tion are associated with mononuclear cell infiltrates and are characteristic pathologic responses in tuberculosis. To identify host cell genes involved in tuberculous pathology, we screened macrophage cDNA libraries for genes induced by mycobacterial infection. One gene isolated in this screen, osteopontin (also known as early T lymphocyte activation protein 1 or Eta-1), was of particular interest because it is a cytokine and macrophage chemoattractant.

机译：慢性炎症和肉芽肿形成与单核细胞浸润有关，是结核病的典型病理反应。为了鉴定参与结核病病理的宿主细胞基因，我们筛选了巨噬细胞cDNA文库中由分枝杆菌感染诱导的基因。在此筛选中分离出的一个基因骨桥蛋白（也称为早期T淋巴细胞活化蛋白1或Eta-1）特别令人感兴趣，因为它是一种细胞因子和巨噬细胞趋化因子。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第12期|p.6414-6419|共6页
作者
Gerard J. Nau; Patrick Guilfoile; Geoffrey L. Chupp;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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6. A chemoattractant cytokine associated with granulomas in tuberculosis and silicosis [O] . Gerard J. Nau, Patrick Guilfoile, Geoffrey L. Chupp, 1997

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A chemoattractant cytokine associated with granulomas in tuberculosis and silicosis

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