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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >A new member of the tumor necrosis factorerve growth factor receptor family inhibits T cell receptor-induced apoptosis
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A new member of the tumor necrosis factorerve growth factor receptor family inhibits T cell receptor-induced apoptosis

机译:肿瘤坏死因子/神经生长因子受体家族的新成员抑制T细胞受体诱导的细胞凋亡

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摘要

By comparing untreated and dexametha- sone-treated murine T cell hybridoma (3DO) cells by the differential display technique, we have cloned a new gene, GITR (glucocorticoid-induced tumor necrosis factor receptor family-related gene) encoding a new member of the tumor necrosis factorerve growth factor receptor family. GITR is a 228-amino acids type I transmembrane protein character- ized by three cysteine pseudorepeats in the extracellular domain and similar to CD27 and 4-1BB in the intracellular domain.
机译:通过差异显示技术比较未处理的和地塞米松处理的鼠T细胞杂交瘤(3DO)细胞,我们克隆了一个新基因GITR(糖皮质激素诱导的肿瘤坏死因子受体家族相关基因),该基因编码该新成员。肿瘤坏死因子/神经生长因子受体家族。 GITR是一种228个氨基酸的I型跨膜蛋白,其特征是胞外域中的三个半胱氨酸假重复序列,与胞内域中的CD27和4-1BB相似。

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