CCAAT/enhancer binding protein ε is preferentially up-regulated during granulocytic differentiation and its functional versatility is determined by alternative use of promoters and differential splicing

Ryuya Yamanaka; Gun-Do Kim; Hanna S. Radomska

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CCAAT/enhancer binding protein ε is preferentially up-regulated during granulocytic differentiation and its functional versatility is determined by alternative use of promoters and differential splicing

机译：CCAAT /增强子结合蛋白ε在粒细胞分化过程中优先上调，其功能多样性由启动子和差异剪接的交替使用决定

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CCAAT/enhancer binding protein (C/EBP) ε is a recently cloned member of the C/EBP family of transcription factors and is expressed exclusively in cells of hematopoietic origin. The human C/EBP gene is transcribed by two alternative promoters, Pα and Pβ. A combination of differential splicing and alternative use of promoters gener- ates four mRNA isoforms, of 2.6 kb and 1.3-1.5 kb in size. These transcripts can encode three proteins of calculated molecular mass 32.2 kDa, 27.8 kDa, and 14.3 kDa.

机译：CCAAT /增强子结合蛋白（C / EBP）ε是C / EBP转录因子家族的最新克隆成员，仅在造血起源的细胞中表达。人C / EBP基因由两个替代启动子Pα和Pβ转录。差异剪接和启动子的替代使用相结合，产生了两种大小分别为2.6 kb和1.3-1.5 kb的mRNA同工型。这些转录本可以编码三种分子量分别为32.2 kDa，27.8 kDa和14.3 kDa的蛋白质。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第12期|p.6462-6467|共6页
作者
Ryuya Yamanaka; Gun-Do Kim; Hanna S. Radomska;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Temporal expression of the human alcohol dehydrogenase gene family during liver development correlates with differential promoter activation by hepatocyte nuclear factor 1, CCAAT/enhancer-binding protein alpha, liver activator protein, and D-element-binding protein. [J] . C van Ooij, R C Snyder, B W Paeper, Molecular and Cellular Biology . 1992,第7期

机译：肝脏发育过程中人酒精脱氢酶基因家族的时间表达与肝细胞核因子1，CCAAT /增强子结合蛋白α，肝激活蛋白和D元素结合蛋白的启动子激活差异有关。
2. The SHP2-ERK2 signaling pathway regulates branched I antigen formation by controlling the binding of CCAAT/enhancer binding protein alpha to the IGnTC promoter region during erythroid differentiation [J] . Liao Yi-Jen, Lee Yen-Hua, Chang Fu-Ling, Transfusion: The Journal of the American Association of Blood Banks . 2016,第11期

机译：SHP2-ERK2信号通路通过在红系分化过程中控制CCAAT /增强子结合蛋白α与IGnTC启动子区域的结合来调节I分支抗原的形成。
3. Enhanced CCAAT/enhancer-binding protein beta-liver-enriched inhibitory protein production by Oltipraz, which accompanies CUG repeat-binding protein-1 (CUGBP1) RNA-binding protein activation, leads to inhibition of preadipocyte differentiation. [J] . Bae EJ, Kim SG Molecular pharmacology. . 2005,第3期

机译：Oltipraz增强了CCAAT /增强子结合蛋白富含β-肝的抑制蛋白的产生，其伴随CUG重复结合蛋白1（CUGBP1）RNA结合蛋白的激活，导致前脂肪细胞分化的抑制。
4. CCAAT/Enhancer-Binding Protein Beta Controls Differentiation-Specific Expression of Chromatin Remodeling Factor BRM [C] . Toshinari Itoh, Katsuhide Miyake, Shinji Iijima Annual Meeting of the Japanese Association for Animal Cell Technology . 2009

机译：CCAAT / Enhancer结合蛋白β控制染色质重塑因子BRM的分化特异性表达
5. In vitro DNA-binding studies of cyclic AMP responsive element binding protein and CCAAT/enhancer binding protein beta. [D] . Popova, Katerina. 2004

机译：环状AMP响应元件结合蛋白和CCAAT /增强子结合蛋白β的体外DNA结合研究。
6. CCAAT/enhancer binding protein ɛ is preferentially up-regulated during granulocytic differentiation and its functional versatility is determined by alternative use of promoters and differential splicing [O] . Ryuya Yamanaka, Gun-Do Kim, Hanna S. Radomska, 1997

机译：CCAAT /增强子结合蛋白gran在粒细胞分化过程中优先上调其功能多样性由启动子和差异剪接的交替使用决定
7. CCAAT/enhancer binding protein is preferentially up-regulated during granulocytic differentiation and its functional versatility is determined by alternative use of promoters and differential splicing [O] . R. Yamanaka, G.-D. Kim, H. S. Radomska, 1997

机译：在粒细胞分化期间优先上调CCAAT / Enhancer结合蛋白，并且通过替代使用启动子和差动剪接来确定其功能性友好性
8. Regulating Prostate Cancer Sensitivity to Chemotherapy through Translational Control of CCAAT/Enhancer Binding Proteins. [R] . Barakat, D. J. 2016

机译：通过CCaaT /增强子结合蛋白的翻译控制调节前列腺癌对化学疗法的敏感性。

CCAAT/enhancer binding protein ε is preferentially up-regulated during granulocytic differentiation and its functional versatility is determined by alternative use of promoters and differential splicing

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