Expression of a gene encoding a tRNA synthetase-like protein is enhanced in tumorigenic human myeloid leukemia cells and is cell cycle stage- and differentiation-dependent

Subrata Sen; Hongyi Zhou; Tracy Ripmaster

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Expression of a gene encoding a tRNA synthetase-like protein is enhanced in tumorigenic human myeloid leukemia cells and is cell cycle stage- and differentiation-dependent

机译：编码tRNA合成酶样蛋白的基因的表达在致瘤性人类髓样白血病细胞中得到增强，并且是细胞周期阶段和分化依赖性的

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We cloned a tumorigenic phenotype- associated cDNA encoding a tRNA synthetase-like protein from an acute-phase human myeloid leukemia cell line. The cDNA was isolated by reiterative subtraction of cDNAs syn- thesized from tumor-generating parental leukemia cells ver- sus those from a nontumorigenic variant of the same cells. The selected cDNA encodes a protein that is a close homolog of one subunit of prokaryote and yeast phenylalanyl-tRNA syn- thetase (PheRS). The expressed protein reacts specificially with polyclonal antibodies raised against mammalian pheny- lalanyl-tRNA synthetase.

机译：我们从急性期人类髓样白血病细胞系中克隆了编码tRNA合成酶样蛋白的致瘤表型相关cDNA。通过反复减去从产生肿瘤的亲代白血病细胞合成的cDNA与来自相同细胞的非致瘤变异株的cDNA的方法，来分离cDNA。选定的cDNA编码一种蛋白质，该蛋白质与原核生物和酵母苯丙氨酰-tRNA合成酶（PheRS）的一个亚基紧密同源。所表达的蛋白质与针对哺乳动物苯丙氨酸-tRNA合成酶的多克隆抗体发生特异性反应。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第12期|p.6164-6169|共6页
作者
Subrata Sen; Hongyi Zhou; Tracy Ripmaster;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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6. Expression of a gene encoding a tRNA synthetase-like protein is enhanced in tumorigenic human myeloid leukemia cells and is cell cycle stage- and differentiation-dependent [O] . Subrata Sen, Hongyi Zhou, Tracy Ripmaster, 1997

机译：编码tRNA合成酶样蛋白的基因在致瘤性人类髓样白血病细胞中的表达增强并且是细胞周期阶段和分化依赖性的
7. Expression of a gene encoding a tRNA synthetase-like protein is enhanced in tumorigenic human myeloid leukemia cells and is cell cycle stage- and differentiation-dependent [O] . S. Sen, H. Zhou, T. Ripmaster, 1997

机译：在致瘤人髓性白血病细胞中增强了编码TRNA合成酶样蛋白的基因的表达，是细胞周期阶段和分化依赖性

Expression of a gene encoding a tRNA synthetase-like protein is enhanced in tumorigenic human myeloid leukemia cells and is cell cycle stage- and differentiation-dependent

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