High-affinity binding of the Drosophila Numb phosphotyrosine- binding domain to peptides containing a Gly-Pro-(p)Tyr motif

Shun-Cheng Li; Zhou Songyang; Sebastien J. F. Vincent

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High-affinity binding of the Drosophila Numb phosphotyrosine- binding domain to peptides containing a Gly-Pro-(p)Tyr motif

机译：果蝇Numb磷酸酪氨酸结合域与含有Gly-Pro-（p）Tyr基序的肽的高亲和力结合

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摘要

The phosphotyrosine-binding (PTB) domain is a recently identified protein module that has been charac- terized as binding to phosphopeptides containing an NPXpY motif (X = any amino acid). We describe here a novel peptide sequence recognized by the PTB domain from Drosophila Numb (dNumb), a protein involved in cell fate determination and asymmetric cell division during the development of the Drosophila nervous system. Using a Tyr-oriented peptide library to screen for ligands, the dNumb PTB domain was found to bind selectively to peptides containing a YIGPYφ motif (φ represents a hydrophobic residue).

机译：磷酸酪氨酸结合（PTB）结构域是最近鉴定的蛋白质模块，其特征是与含有NPXpY基序（X =任何氨基酸）的磷酸肽结合。我们在这里描述了一种由果蝇Numb（dNumb）的PTB域识别的新型肽序列，该蛋白质参与果蝇神经系统发育过程中的细胞命运确定和不对称细胞分裂。使用面向Tyr的肽库筛选配体，发现dNumb PTB结构域与含有YIGPYφ基序的肽（φ代表疏水残基）选择性结合。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第14期|p.7204-7209|共6页
作者
Shun-Cheng Li; Zhou Songyang; Sebastien J. F. Vincent;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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6. High-affinity binding of the Drosophila Numb phosphotyrosine-binding domain to peptides containing a Gly-Pro-(p)Tyr motif [O] . Shun-Cheng Li, Zhou Songyang, Sébastien J. F. Vincent, 1997

机译：果蝇Numb磷酸酪氨酸结合域与含有Gly-Pro-（p）TyrTmotif的肽的高亲和力结合
7. High-affinity binding of the Drosophila Numb phosphotyrosine-binding domain to peptides containing a Gly-Pro-(p)Tyr motif [O] . S.-C. Li, Z. Songyang, S. J. F. Vincent, 1997

机译：果蝇Numb phospophyrosine结合结构域的高亲和力结合至含有Gly-pro-pro-pro-pro-（p）tyr主题的肽

High-affinity binding of the Drosophila Numb phosphotyrosine- binding domain to peptides containing a Gly-Pro-(p)Tyr motif

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