Silent chromatin determines target preference of the Saccharomyces retrotransposon Ty5

Sige Zou; Daniel F. Voytas

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Silent chromatin determines target preference of the Saccharomyces retrotransposon Ty5

机译：沉默的染色质确定酵母逆转录转座子Ty5的目标偏好。

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The HML and HMR mating loci of Saccha- romyces cerevisiae are bound in silent chromatin, which is assembled at the flanking E and I transcriptional silencers. The retrotransposon Ty5 preferentially integrates into regions of silent chromatin, and Ty5 insertions near the HMR-E silencer account for ≈2/100 of total transposition events. Most Ty5 insertions occur within 800 bp on either side of the autonomously replicating consensus sequence within HMR-E. Ty5 target preference is determined by silent chromatin, because integration near HMR-E is abolished in strains with silencer mutations that alleviate transcriptional repression.

机译：酿酒酵母的HML和HMR交配位点结合在沉默的染色质中，该染色质在侧翼的E和I转录沉默子处组装。逆转录转座子Ty5优先整合到沉默染色质区域中，靠近HMR-E沉默子的Ty5插入占总转座事件的约2/100。大多数Ty5插入发生在HMR-E中自主复制共有序列两侧的800 bp之内。 Ty5靶标的优先选择取决于沉默的染色质，因为在具有减轻转录抑制作用的沉默子突变的菌株中，HMR-E附近的整合被取消了。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第14期|p.7412-7416|共5页
作者
Sige Zou; Daniel F. Voytas;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Targeting of the Yeast Ty5 Retrotransposon to Silent Chromatin Is Mediated by Interactions between Integrase and Sir4p [J] . Weiwu Xie, Xiaowu Gai, Yunxia Zhu, Molecular and Cellular Biology . 2001,第19期

机译：酵母Ty5反转录转座子沉默染色质的靶向是由整合酶和Sir4p之间的相互作用介导的。
2. A Single Amino Acid Change in the Yeast Retrotransposon Ty5 Abolishes Targeting to Silent Chromatin [J] . Xiaowu Gai, Daniel F. Voytas Molecular cell . 1998,第7期

机译：酵母逆转录转座子Ty5中的单个氨基酸改变废除了靶向沉默的染色质
3. cDNA of the Yeast Retrotransposon Ty5 Preferentially Recombines with Substrates in Silent Chromatin [J] . Ning Ke, Daniel F. Voytas Molecular and Cellular Biology . 1999,第1期

机译：酵母逆转录转座子Ty5的cDNA优先与沉默染色质中的底物重组。
4. Multiple pathways tether telomeres and silent chromatin at the nuclear periphery: functional implications for Sir-mediated repression [C] . Angela Taddei, Marc R. Gartenberg, Frank R. Neumann, Novartis Foundation symposium on Nuclear organization in development and disease . 2005

机译：核外围的多种途径系粒细胞溶剂和沉默染色质：针对先生介导的抑制功能影响
5. Sir3 and epigenetic inheritance of silent chromatin in Saccharomyces cerevisiae. [D] . Motwani, Tina. 2012

机译：Sir3和酿酒酵母沉默染色质的表观遗传。
6. Silent chromatin determines target preference of the Saccharomyces retrotransposon Ty5 [O] . Sige Zou, Daniel F. Voytas 1997

机译：沉默的染色质决定了酿酒酵母逆转录转座子Ty5的靶标偏好
7. The pheromone response pathway activates transcription of Ty5 retrotransposons located within silent chromatin of Saccharomyces cerevisiae. [O] . Ke, N, Irwin, P A, Voytas, D F 1997

机译：信息素反应途径激活位于酿酒酵母无性染色质内的Ty5逆转座子的转录。

Silent chromatin determines target preference of the Saccharomyces retrotransposon Ty5

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