Thymineless death in colon carcinoma cells is mediated via Fas signaling

Janet A. Houghton; Franklin G. Harwood; David M. Tillman

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Thymineless death in colon carcinoma cells is mediated via Fas signaling

机译：结肠癌细胞中无胸腺嘧啶的死亡通过Fas信号转导介导

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Fas is expressed constitutively in colonic epithelial cells and is also expressed in colon carcinomas and in cultured colon carcinoma cell lines. However, the potential role of Fas signaling in mediating apoptosis in cells of this type remains unknown. We have developed human colon carci- noma cell models deficient in thymidylate synthase that demonstrate acute (TS~- cells) or delayed (Thy4 cells) apo- ptosis following DNA damage induced by thymineless stress. Complete protection of cells from acute apoptosis and pro- longation of delayed apoptosis was obtained following expo- sure to the NOK-1 monoclonal antibody (inhibitory to Fas signaling) during the period of dThd deprivation.

机译：Fas在结肠上皮细胞中组成性表达，在结肠癌和培养的结肠癌细胞系中也表达。但是，Fas信号介导这种类型的细胞凋亡的潜在作用仍然未知。我们开发了缺乏胸苷酸合酶的人结肠癌细胞模型，该模型显示了无胸腺嘧啶应激诱导的DNA损伤后的急性（TS〜-细胞）或延迟的（Thy4细胞）凋亡。在dThd剥夺期间暴露于NOK-1单克隆抗体（抑制Fas信号转导）后，可以完全保护细胞免受急性凋亡和延迟凋亡的延长。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第15期|p.8144-8149|共6页
作者
Janet A. Houghton; Franklin G. Harwood; David M. Tillman;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Ru(II)-thymine complex causes DNA damage and apoptotic cell death in human colon carcinoma HCT116 cells mediated by JNK/p38/ERK1/2 via a p53-independent signaling [J] . Suellen L. R. Silva, Ingrid R. S. Baliza, Rosane B. Dias, Scientific reports. . 2019,第1期

机译：Ru（ii）-Thymine综合体通过P53独立的信号传导使DNA损伤和由JNK / P38 / ERK1 / 2介导的人结肠癌HCT116细胞中的凋亡细胞死亡
2. Sialylation of the Fas Death Receptor by ST6Gal-I Provides Protection against Fas-mediated Apoptosis in Colon Carcinoma Cells [J] . Amanda Swindall, Susan L. Bellis The Journal of biological chemistry . 2011,第26期

机译：ST6GAL-I的FAS死亡受体的唾液酸化提供了对结肠癌细胞的Fas介导的细胞凋亡的保护
3. Defects in death-inducing signalling complex formation prevent JNK activation and Fas-mediated apoptosis in DU 145 prostate carcinoma cells [J] . J F Curtin, T G Cotter British Journal of Cancer . 2003,第10期

机译：死亡诱导信号复合物形成的缺陷阻止DU 145前列腺癌细胞的JNK活化和Fas介导的细胞凋亡
4. Development of a Phosphoproteomics Approach to Study GPCR-Mediated Signaling Events in a Human Prostate Carcinoma Cell Line [C] . Heike Piechura, Christian Bunse, Sebastian Wiese, ASMS Conference on Mass Spectrometry and Allied Topics . 2008

机译：磷蛋白质方法研究人道前列腺癌细胞中GPCR介导的信号传导事件的发展
5. Receptor-mediated interactions of polymorphonuclear leukocytes with colon carcinoma cells and selectin substrates under shear. [D] . Jadhav, Sameer R. 2005

机译：剪切作用下多形核白细胞与结肠癌细胞和选择素底物的受体介导相互作用。
6. Thymineless death in colon carcinoma cells is mediated via Fas signaling [O] . Janet A. Houghton, Franklin G. Harwood, David M. Tillman 1997

机译：结肠癌细胞无胸腺嘧啶的死亡通过 Fas信号介导
7. Ru(II)-thymine complex causes DNA damage and apoptotic cell death in human colon carcinoma HCT116 cells mediated by JNK/p38/ERK1/2 via a p53-independent signaling [O] . Suellen L. R. Silva, Ingrid R. S. Baliza, Rosane B. Dias, 2019

机译：Ru（ii）-Thymine综合体通过P53独立的信号传导使DNA损伤和由JNK / P38 / ERK1 / 2介导的人结肠癌HCT116细胞中的凋亡细胞死亡

Thymineless death in colon carcinoma cells is mediated via Fas signaling

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