Anteroposterior neural tissue specification by activin-induced mesoderm

Jeremy B. A. Green; T. Les Cook; J. C. Smith

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Anteroposterior neural tissue specification by activin-induced mesoderm

机译：激活素诱导的中胚层的前后神经组织规格

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The transforming growth factor β superfam- ily member, activin, is able to induce mesodermal tissues in animal cap explants from Xenopus laevis blastula stage em- bryos. Activin can act like a morphogen of the dorsoventral axis in that lower doses induce more ventral, and higher doses more dorsal, tissue types. Activin has also previously been reported to induce neural tissues in animal caps. From cell mixing experiments it was inferred that this might be an indirect effect of induced mesoderm signaling to uninduced ectoderm. Here we demonstrate directly that neural tissues do indeed arise by the action of induced mesoderm on uninduced ectoderm.

机译：转化生长因子β超家族成员激活素能够在非洲爪蟾囊胚期胚的动物帽外植体中诱导中胚层组织。激活素可以像背腹轴的形态发生子一样起作用，因为较低的剂量诱导更多的腹侧，较高的剂量诱导更多的背侧组织类型。先前还已经报道了激活素可以诱导动物帽中的神经组织。从细胞混合实验中推断，这可能是诱导的中胚层信号传导到未诱导的外胚层的间接作用。在这里，我们直接证明神经组织确实是由中胚层对未诱导外胚层的作用而产生的。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第16期|p.8596-8601|共6页
作者
Jeremy B. A. Green; T. Les Cook; J. C. Smith;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Expression Patterns of Hoxb Genes in the Xenopus Embryo Suggest Roles in Anteroposterior Specification of the Hindbrain and in Dorsoventral Patterning of the Mesoderm [J] . Susan Godsave, Erik-Jan Dekker, Tjadine Holling, Developmental biology . 1994,第2期

机译：在非洲爪蟾胚胎中Hoxb基因的表达模式表明在后脑的后部规范和中胚层的背腹模式中的作用
2. SPECIFICATION OF THE ANTEROPOSTERIOR NEURAL AXIS THROUGH SYNERGISTIC INTERACTION OF THE WNT SIGNALING CASCADE WITH NOGGIN AND FOLLISTATIN [J] . Mcgrew LL., Moon RT., Lai CJ. Developmental biology . 1995,第1期

机译：WNT信号级联与Noggin和Follistatin的协同相互作用对前后骨神经元轴的规范
3. Specification of the Anteroposterior Neural Axis through Synergistic Interaction of the Wnt Signaling Cascade withnogginandfollistatin [J] . L.Lynn McGrew, Cheng-Jung Lai, Randall T. Moon Developmental biology . 1995,第1期

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4. Induction of Neural Lineages from Mesoderm and Endoderm by Defined Transcription Factors [C] . Marius Wernig Fondation IPSEN pour la recherche the?rapeutique, Meeting . 2013

机译：通过定义的转录因子诱导Mesoderm和内胚层的神经谱系
5. Glucocorticoid receptor directs cardiogenic mesoderm specification in murine embryonic stem cells by induction of cardiogenic factors in endoderm. [D] . Cabral Teixeira, Joaquim Miguel. 2011

机译：糖皮质激素受体通过诱导内胚层中的心源性因子指导小鼠胚胎干细胞中的心源性中胚层规格。
6. Anteroposterior neural tissue specification by activin-induced mesoderm [O] . Jeremy B. A. Green, T. Les Cook, J. C. Smith, 1997

机译：激活素诱导的中胚层的前后神经组织规格
7. Anteroposterior neural tissue specification by activin-induced mesoderm [O] . J. B. A. Green, T. L. Cook, J. C. Smith, 1997

机译：活性素诱导的中胚层的前后神经组织规范

Anteroposterior neural tissue specification by activin-induced mesoderm

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