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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >DNA immunization circumvents deficient induction of T helper type 1 and cytotoxic T lymphocyte responses in neonates and during early life
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DNA immunization circumvents deficient induction of T helper type 1 and cytotoxic T lymphocyte responses in neonates and during early life

机译：DNA免疫可避免在新生儿及早年期间对1型T辅助细胞和细胞毒性T淋巴细胞反应的诱导不足。

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摘要

The relative deficiency of T helper type 1 (Th1) and cytotoxic T lymphocyte (CTL) responses in early life is associated with an increased susceptibility to infections by intracellular microorganisms. This is likely to reflect a preferential polarization of immature CD4 T cells toward a Th2 rather than a Th1 pattern upon immunization with conventional vaccines. In this report, it is shown that a single immunization within the first week of life with DNA plasmids encoding viral (measles virus hemagglutinin, Sendai virus nucleoprotein) or bacterial (C fragment of tetanus toxin) vaccine antigens can induce adult-like Th1 or mixed Th1/Th2 responses indicated by production of IgG2a vaccine-specific antibodies and preferential secretion of interferon-γ (IFN-γ) compared with interleukin (IL)-5 by antigen-specific T cells, as well as significant CTL responses.
机译：早期生命中T辅助1型（Th1）和细胞毒性T淋巴细胞（CTL）反应的相对缺乏与细胞内微生物感染的易感性增加有关。用常规疫苗免疫后，这很可能反映出未成熟的CD4 T细胞朝着Th2模式而非Th1模式的优先极化。在此报告中显示，在出生后第一周内，使用编码病毒（麻疹病毒血凝素，仙台病毒核蛋白）或细菌（破伤风毒素C片段）疫苗的DNA质粒进行单次免疫可以诱导成年型Th1或混合型Th1 / Th2响应由抗原特异性T细胞产生的IgG2a疫苗特异性抗体和与白介素（IL）-5相比优先分泌干扰素-γ（IFN-γ）以及明显的CTL响应指示。

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