Cisplatin increases meiotic crossing-over in mice

William H. Hanneman; Marie E. Legare; Shannon Sweeney

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Cisplatin increases meiotic crossing-over in mice

机译：顺铂增加小鼠减数分裂的转换

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Genetic mapping of traits and mutations in mammals is dependent upon linkage analysis. The resolution achieved by this method is related to the number of offspring that can be scored and position of crossovers near a gene. Higher precision mapping is obtained by expanding the collection of progeny from an appropriate cross, which in turn increases the number of potentially informative recombinants. A more efficient approach would be to increase the frequency of recombination, rather than the number of progeny.

机译：哺乳动物性状和突变的遗传作图取决于连锁分析。通过这种方法获得的分辨率与可计分的后代数量以及基因附近的交换位置有关。通过扩大来自适当杂交的子代的收集，可以获得更高精度的作图，这反过来又增加了可能提供信息的重组子的数量。一种更有效的方法是增加重组的频率，而不是后代的数量。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第16期|p.8681-8685|共5页
作者
William H. Hanneman; Marie E. Legare; Shannon Sweeney;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Impaired meiotic DNA-damage repair and lack of crossing-over during spermatogenesis in BRCA1 full-length isoform deficient mice. [J] . Xu X, Moens P, Furth PA Development . 2003,第9期

机译：减数分裂DNA损伤修复和BRCA1全长亚型缺陷小鼠精子发生过程中缺乏交叉缺乏。
2. Loss of HR6B Ubiquitin-Conjugating Activity Results in Damaged Synaptonemal Complex Structure and Increased Crossing-Over Frequency during the Male Meiotic Prophase [J] . Willy M. Baarends, Evelyne Wassenaar, Jos W. Hoogerbrugge, Molecular and Cellular Biology . 2003,第4期

机译：HR6B泛素结合活性的丧失导致男性减数分裂前期的联膜复杂结构受损和交叉频率增加
3. SPO16 binds SHOC1 to promote homologous recombination and crossing-over in meiotic prophase I [J] . Qianting Zhang, Shu-Yan Ji, Kiran Busayavalasa, Science Advances . 2019,第1期

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4. Effect of Ethidium Bromide on Meiotic Recombination during Spermatogenisis in Male Mice [C] . Wang Hongying, Cai Xin 5th International Conference on Bioinformatics and Biomedical Engineering . 2011

机译：溴化乙锭对雄性小鼠生精过程中减数分裂重组的影响
5. The regulation of chromatid interactions prevents aberrant crossing-over during meiotic recombination. [D] . Oh, Steve Dojin. 2009

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6. Cisplatin increases meiotic crossing-over in mice [O] . William H. Hanneman, Marie E. Legare, Shannon Sweeney, 1997

机译：顺铂增加小鼠减数分裂的交叉
7. Impaired meiotic DNA-damage repair and lack of crossing-over during spermatogenesis in BRCA1 full-length isoform deficient mice [O] . Xiaoling Xu, Olga Aprelikova, Peter Moens, 2003

机译：在BRCA1全长同种型小鼠中缺乏减少的减震性DNA损伤修复和缺乏穿越缺失

Cisplatin increases meiotic crossing-over in mice

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