Thymocyte development is normal in CTLA-4-deficient mice

Cynthia A. Chambers; Dragana Cado; Thien Truong

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Thymocyte development is normal in CTLA-4-deficient mice

机译：在CTLA-4缺陷小鼠中胸腺细胞发育正常

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Recent studies indicate that CTLA-4 inter- action with B7 ligands transduces an inhibitory signal to T lymphocytes. Mice homozygous for a null mutation in CTLA-4 have provided the most dramatic example of the functional importance of CTLA-4 in vivo. These animals develop a fatal lymphoproliferative disorder and were reported to have an increase in CD4~+ and CD8~+ thymocytes and CD4~-CD8~- thymocytes, and a decrease in CD4+CD8+ thymocytes. Based on these observations, it was proposed that CTLA-4 is nec- essary for normal thymocyte development. In this study, CTLA-4-deficient mice carrying an insertional mutation into exon 3 of the ctla-4 gene were generated.

机译：最近的研究表明，CTLA-4与B7配体的相互作用将抑制信号转导至T淋巴细胞。纯合的CTLA-4无效突变小鼠提供了体内CTLA-4功能重要性的最生动的例子。这些动物发展成致命的淋巴细胞增生性疾病，据报道其CD4 +和CD8 +胸腺细胞和CD4--CD8-胸腺细胞增加，而CD4 + CD8 +胸腺细胞减少。根据这些观察结果，建议正常胸腺细胞发育需要CTLA-4。在这项研究中，生成携带ctla-4基因外显子3插入突变的CTLA-4缺陷小鼠。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第17期|p.9296-9301|共6页
作者
Cynthia A. Chambers; Dragana Cado; Thien Truong;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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6. Thymocyte development is normal in CTLA-4-deficient mice [O] . Cynthia A. Chambers, Dragana Cado, Thien Truong, 1997

机译：在CTLA-4缺陷小鼠中胸腺细胞发育正常
7. Thymocyte development is normal in CTLA-4-deficient mice [O] . C. A. Chambers, D. Cado, T. Truong, 1997

机译：CTLA-4缺陷小鼠的胸腺细胞发育正常
8. Lack of Expression on Cultured Human T-Lymphocytes of a T-Cell Antigen Shared by the Molt-4 Cell Line and Normal Human Thymocytes [R] . Pandolfi, F., Strong, D. M., Bonnard, G. D., 1979

机译：在molt-4细胞系和正常人胸腺细胞共有的T细胞抗原培养的人T淋巴细胞上缺乏表达

Thymocyte development is normal in CTLA-4-deficient mice

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