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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Listeria monocytogenes infection of P388D_1 macrophages results in a biphasic NF-κB (RelA/p50) activation induced by lipoteichoic acid and bacterial phospholipases and mediated by IκBα and IκBβ degradation
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Listeria monocytogenes infection of P388D_1 macrophages results in a biphasic NF-κB (RelA/p50) activation induced by lipoteichoic acid and bacterial phospholipases and mediated by IκBα and IκBβ degradation

机译：单核细胞增生李斯特氏菌感染P388D_1巨噬细胞会导致脂蛋白和细菌磷脂酶诱导并由IκBα和IκBβ降解介导的双相NF-κB（RelA / p50）活化

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摘要

As previously reported, Listeria monocyto- genes infection of P388D_1 macrophages results in a rapid induction of NF-κB DNA-binding activity. Here we show that this induction of NF-κB activity occurs in a biphasic mode: first, a transient, I蔅α degradation-dependent phase of ac- tivity, also induced by the nonvirulent species Listeria innocua, which is mediated by binding of the bacteria to the macro- phage, or by adding Listeria-derived lipoteichoic acid to the macrophage; the second persistent phase of activation is only markedly induced when the bacteria enter the cytoplasm of the host cell and express the virulence genes plcA and plcB, encoding two phospholipases.
机译：如先前报道的，李斯特菌单核细胞基因感染P388D_1巨噬细胞可导致快速诱导NF-κBDNA结合活性。在这里，我们表明这种诱导NF-κB活性的过程是双相的：首先，瞬变的I蔅α降解依赖型活性，也由非毒性物种无毒李斯特菌诱导，这是通过结合细菌进入巨噬细胞，或在巨噬细胞中加入利斯特氏菌衍生的脂蛋白酸；仅当细菌进入宿主细胞的细胞质并表达编码两种磷脂酶的毒力基因plcA和plcB时，才激活第二个持续激活阶段。

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