Correlates of latent and productive HIV type-1 infection in tonsillar CD4~+ T cells

Bard Rosok; Jan E. Brinchmann; Pal Voltersvik

首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Correlates of latent and productive HIV type-1 infection in tonsillar CD4~+ T cells

【24h】

Correlates of latent and productive HIV type-1 infection in tonsillar CD4~+ T cells

机译：扁桃体CD4〜+ T细胞中潜在和生产性HIV 1型感染的相关性

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Correlates of virus load and characteristics of virus-producing cells in tonsillar tissue were investigated. Our results suggest that when less than 1:100 tonsillar CD4~+ T cells from individuals infected with HIV type-1 (HIV-1) contain replication competent provirus, the level of CD4~+ T cells in tonsils is comparable to that observed in uninfected individuals. Virus load at or above this level was associated with low CD4 cell numbers in tonsillar tissue. Only a few percent of all infected T cells in tonsillar tissue were active virus producers, with minor differences observed between individuals. Plasma viremia was found to correlate with infectious virus load in tonsillar tissue.

机译：研究了扁桃体组织中病毒载量与病毒产生细胞的相关性。我们的结果表明，当来自感染1型HIV（HIV-1）的个体的扁桃体CD4〜+ T细胞少于1：100含有能复制的原病毒时，扁桃体中CD4〜+ T细胞的水平与在鼻咽癌中观察到的水平相当。未感染的个体。达到或高于此水平的病毒载量与扁桃体组织中CD4细胞数量低有关。扁桃体组织中所有感染的T细胞中只有百分之几是活跃的病毒生产者，个体之间观察到很小的差异。发现血浆病毒血症与扁桃体组织中的感染性病毒载量相关。

著录项

来源
《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第17期|p.9332-9336|共5页
作者
Bard Rosok; Jan E. Brinchmann; Pal Voltersvik;
展开▼
作者单位

展开▼
收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词

相似文献

外文文献
中文文献
专利

1. Lymphatic endothelial cells promote productive and latent HIV infection in resting CD4+ T cells [J] . Meghan Schilthuis, Seth Verkaik, Mackenzie Walhof, Virology Journal . 2018,第1期

机译：淋巴管内皮细胞促进静息CD4 + T细胞中生产性和潜伏性HIV感染
2. NNRTI-induced HIV-1 protease-mediated cytotoxicity induces rapid death of CD4 T cells during productive infection and latency reversal [J] . Benjamin Trinité, Hongtao Zhang, David N. Levy Retrovirology . 2019,第1期

机译：NNRTI诱导的HIV-1蛋白酶介导的细胞毒性在生产性感染和延迟逆转期间诱导CD4 T细胞的快速死亡
3. Heterogeneity in HIV and cellular transcription profiles in cell line models of latent and productive infection: implications for HIV latency [J] . Sushama Telwatte, Sara Morón-López, Dvir Aran, Retrovirology . 2019,第1期

机译：潜伏和生产性感染细胞系模型中HIV和细胞转录谱的异质性：HIV潜伏的影响
4. Synergetic control for HIV infection system of CD4+T cells [C] . Arsit Boonyaprapasorn, Parinya Sa Ngiamsunthorn, Thunyaseth Sethaput International conference on control, automation and systems . 2016

机译：CD4 + T细胞HIV感染系统的协同控制
5. Identifying Correlates of Immune-Mediated Elimination of Productively and Latently HIV-Infected T Cells [D] . Flerin, Nina. 2018

机译：识别免疫介导的生产性和潜伏性HIV感染T细胞消除的相关性
6. Correlates of latent and productive HIV type-1 infection in tonsillar CD4+ T cells [O] . Bård Røsok, Jan E. Brinchmann, Pål Voltersvik, 1997

机译：扁桃体CD4 + T细胞中潜在和生产性HIV 1型感染的相关性
7. HIV-1-Infected CD4+ T Cells Facilitate Latent Infection of Resting CD4+ T Cells through Cell-Cell Contact [O] . Luis M. Agosto, Melissa B. Herring, Walther Mothes, 2018

机译：HIV-1感染的CD4 + T细胞促进通过细胞 - 细胞接触静息CD4 + T细胞的潜在感染

Correlates of latent and productive HIV type-1 infection in tonsillar CD4~+ T cells

摘要

著录项

相似文献

相关主题

期刊订阅