Deltorphin transport across the blood-brain barrier

Anna Fiori; Patrizia Cardelli; Lucia Negri

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Deltorphin transport across the blood-brain barrier

机译：Deltorphin通过血脑屏障的转运

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In vivo antinociception studies demonstrate that deltorphins are opioid peptides with an unusually high blood-brain barrier penetration rate. In vitro, isolated bovine brain microvessels can take up deltorphins through a satu- rable nonconcentrative permeation system, which is appar- ently distinct from previously described systems involved in the transport of neutral amino acids or of enkephalins. Removing Na~+ ions from the incubation medium decreases the carrier affinity for deltorphins (-25/100), but does not affect the V_max value of the transport.

机译：体内抗伤害感受研究表明，德尔托芬是具有异常高的血脑屏障穿透率的阿片类肽。在体外，离体的牛脑微血管可以通过可饱和的非浓缩渗透系统吸收三聚吗啡，该系统显然不同于先前描述的涉及中性氨基酸或脑啡肽运输的系统。从孵育介质中除去Na〜+离子会降低载体对deltorphins的亲和力（-25/100），但不会影响转运蛋白的V_max值。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第17期|p.9469-9474|共6页
作者
Anna Fiori; Patrizia Cardelli; Lucia Negri;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Structure-activity relationships of a series of (D-Ala2)deltorphin I and II analogues; in vitro blood-brain barrier permeability and stability. [J] . Thomas SA, Abbruscato TJ, Hau VS, The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 1997,第2期

机译：一系列（D-Ala2）deltorphin I和II类似物的构效关系;体外血脑屏障的通透性和稳定性。
2. PERMEABILITY OF THE BLOOD-BRAIN BARRIER AND TRANSPORT OF NANOBODIES ACROSS THE BLOOD-BRAIN BARRIER [J] . Sirochmanova. I, Comor. L, Kanova. E, Folia Veterinaria . 2018,第1期

机译：血脑屏障的渗透性和血型脑屏障的纳米级运输
3. Blood-brain barrier permeability correlates with medial temporal lobe atrophy but not with amyloid-beta protein transport across the blood-brain barrier in Alzheimer's disease. [J] . Matsumoto Y, Yanase D, Noguchi-Shinohara M, Dementia and geriatric cognitive disorders . 2007,第4期

机译：在阿尔茨海默氏病中，血脑屏障通透性与内侧颞叶萎缩相关，但与淀粉样蛋白跨血脑屏障的转运无关。
4. TARGETING THE SODIUM DEPENDENT MULTIVITAMIN TRANSPORTER (SMVT) IN THE BLOOD-BRAIN BARRIER (BBB) TO INCREASE THE TRANSPORT OF BIOTIN CONJUGATED PEPTIDES AND POLYMERS [C] . S. Park, S. Stein, P. J. Sinko International symposium on controlled release of bioactive materials;Consumer diversified products conference . 2001

机译：在血脑屏障（BBB）中定位依赖钠的多维生素转运蛋白（SMVT）以增加生物素共轭肽和聚合物的转运
5. Hypoxia/reoxygenation stress modulates atorvastatin transport at the blood-brain barrier: A role for organic anion transporting polypeptide. [D] . Thompson, Brandon. 2014

机译：缺氧/复氧应激可调节血脑屏障中的阿托伐他汀转运：有机阴离子转运多肽的作用。
6. Deltorphin transport across the blood–brain barrier [O] . Anna Fiori, Patrizia Cardelli, Lucia Negri, 1997

机译：Deltorphin通过血脑屏障的转运
7. Deltorphin transport across the blood-brain barrier [O] . Anna Fiori, Patrizia Cardelli, Lucia Negri, 1997

机译：Deltorphin通过血脑屏障的转运

Deltorphin transport across the blood-brain barrier

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