Expanding the functional human mitochondrial DNA database by the establishment of primate xenomitochondrial cybrids

Lesley Kenyon; Carlos T. Moraes

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Expanding the functional human mitochondrial DNA database by the establishment of primate xenomitochondrial cybrids

机译：通过建立灵长类动物线粒体杂种来扩展功能性人类线粒体DNA数据库

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The nuclear and mitochondrial genomes co- evolve to optimize approximately 100 different interactions necessary for an efficient ATP-generating system. This coevo- lution led to a species-specific compatibility between these genomes. We introduced mitochondrial DNA (mtDNA) from different primates into mtDNA-less human cells and selected for growth of cells with a functional oxidative phosphorylation system. mtDNA from common chimpanzee, pigmy chimpan- zee, and gorilla were able to restore oxidative phosphorylation in the context of a human nuclear background, whereas mtDNA from orangutan, and species representative of Old- World monkeys, New-World monkeys, and lemurs were not.

机译：核和线粒体基因组共同进化，以优化高效ATP生成系统所需的约100种不同的相互作用。这项合作导致了这些基因组之间的物种特异性相容性。我们将来自不同灵长类的线粒体DNA（mtDNA）引入了无mtDNA的人类细胞中，并选择了具有功能性氧化磷酸化系统的细胞进行生长。在人类核背景下，来自普通黑猩猩，猪黑猩猩和大猩猩的mtDNA能够恢复氧化磷酸化，而来自猩猩以及代表旧世界的猴子，新世界的猴子和狐猴的物种的mtDNA不能恢复。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第17期|p.9131-9135|共5页
作者
Lesley Kenyon; Carlos T. Moraes;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Functional respiratory chain analyses in murid xenomitochondrial cybrids expose coevolutionary constraints of cytochrome b and nuclear subunits of complex III [J] . McKenzie M, Chiotis M, Pinkert CA, Molecular biology and evolution . 2003,第7期

机译：多种异种线粒体细胞中的功能性呼吸链分析揭示了细胞色素b和复合物III核亚基的共同进化限制
2. Incompatibility of nucleus and mitochondria causes xenomitochondrial cybrid unviable across human, mouse, and pig cells. [J] . Yu GuangHui, Tian JianHui, Yin JingDong, Animal Biotechnology . 2014,第1a4期

机译：核与线粒体的不相容性导致异种线粒体杂种无法在人，小鼠和猪细胞中存活。
3. Mitochondrial DNA density homeostasis accounts for a threshold effect in a cybrid model of a human mitochondrial disease [J] . Juvid Aryaman, Iain G. Johnston, Nick S. Jones The Biochemical Journal . 2017,第23期

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4. Enhanced Generation of Mitochondrial Reactive Oxygen Species in Cybrids Containing 4977-bp Mitochondrial DNA Deletion [C] . MEI-JIE JOU, TSUNG-I PENG, HONG-YUEH WU, Asian Society for Mitochondrial Research and Medicine . 2005

机译：增强含有4977-BP线粒体DNA缺失的糖线电池活性氧物质的产生
5. Primate Skeletal Epigenetics: Evolutionary Implications of DNA Methylation Patterns in the Skeletal Tissues of Human and Nonhuman Primates [D] . Housman, Genevieve. 2017

机译：灵长类动物骨骼表观遗传学：DNA甲基化模式在人和非人类骨骼组织中的进化意义
6. Expanding the functional human mitochondrial DNA database by the establishment of primate xenomitochondrial cybrids [O] . Lesley Kenyon, Carlos T. Moraes 1997

机译：通过建立灵长类动物线粒体杂种来扩展功能性人类线粒体DNA数据库
7. Functional Respiratory Chain Analyses in Murid Xenomitochondrial Cybrids Expose Coevolutionary Constraints of Cytochrome b and Nuclear Subunits of Complex III [O] . Matthew Mckenzie, Maria Chiotis, Carl A. Pinkert, 2013

机译：功能性呼吸链分析在Murid线粒体杂种暴露细胞色素b和复杂III核亚基的共进化约束。

Expanding the functional human mitochondrial DNA database by the establishment of primate xenomitochondrial cybrids

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