Loss of the gene encoding mannose 6-phosphate/insulin-like growth factor II receptor is an early event in liver carcinogenesis

Tomoya Yamada; Angus T. De Souza; Sydney Finkelstein

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Loss of the gene encoding mannose 6-phosphate/insulin-like growth factor II receptor is an early event in liver carcinogenesis

机译：甘露糖6-磷酸/胰岛素样生长因子II受体编码基因的丢失是肝癌发生的早期事件

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This report shows that loss of heterozygosity at the mannose 6-phosphate/insulin-like growth factor II receptor (M6P/IGF2R) locus occurred in 5/8 (63/100) dysplas- tic liver lesions and 11/18 (61/100) hepatocellular carcinomas (HCCs) associated with the high risk factors of hepatitis virus infection and liver cirrhosis. Mutations in the remaining allele were detected in 6/11 (55/100) HCCs, including deletions in a polydeoxyguanosine region known to be a target of microsat- ellite instability. M6P/IGF2R allele loss was also found in cirrhotic tissue of clonal origin adjacent to these dysplastic lesions and HCCs, demonstrating that M6P/IGF2R inactiva- tion occurs early in liver carcinogenesis.

机译：该报告表明，甘露糖6-磷酸/胰岛素样生长因子II受体（M6P / IGF2R）基因座的杂合性丧失发生在5/8（63/100）发育不良的肝脏病变和11/18（61/100））与肝炎病毒感染和肝硬化的高风险因素相关的肝细胞癌（HCC）。在6/11（55/100）HCC中检测到了剩余等位基因的突变，包括已知是微卫星不稳定性靶点的聚脱氧鸟苷区域中的缺失。 M6P / IGF2R等位基因缺失也在这些不典型增生性病变和HCC邻近的克隆性肝硬化组织中发现，表明M6P / IGF2R失活是在肝癌发生的早期发生的。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第19期|p.10351-10355|共5页
作者
Tomoya Yamada; Angus T. De Souza; Sydney Finkelstein;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Mannose 6-phosphate/insulin-like growth factor II-binding proteins in human serum and urine. Their relation to the mannose 6-phosphate/insulin-like growth factor II receptor [J] . A Waheed, C Causin, K von Figura, The biochemical journal . 1988,第3期

机译：人血清和尿液中的甘露糖6-磷酸/胰岛素样生长因子II结合蛋白。它们与6-磷酸甘露糖/胰岛素样生长因子II受体的关系
2. Loss of heterozygosity of the mannose 6-phosphate/insulin-like growth factor II receptor and p53 genes in human hepatocellular carcinoma. [J] . Kishimoto Y, Kitano M, Horie Y, Hepatology research: the official journal of the Japan Society of Hepatology . 2001,第1期

机译：甘露糖6-磷酸/胰岛素样生长因子II受体和p53基因在人类肝细胞癌中的杂合性丧失。
3. Mutation analysis of the gene encoding the human mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) in human cell lines resistant to growth inhibition by transforming growth factor beta(1) (TGF-beta(1)). [J] . Gemma A, Hosoya Y, Uematsu K, Lung cancer: Journal of the International Association for the Study of Lung Cancer . 2000,第2期

机译：人类细胞系中编码人类甘露糖6-磷酸/胰岛素样生长因子2受体（M6P / IGF2R）的基因的突变分析，可通过转化生长因子beta（1）（TGF-beta（1））来抑制生长。
4. Is the Mannose-6-Phosphate/Insulin-Like Growth Factor 2 Receptor Coded by a Breast Cancer Suppressor Gene? [C] . Guy Joseph Lemamy, Majida Esslimani Sahla, Marie Laurence Berthe, International Symposium on Hormonal Carcinogenesis . 2008

机译：是由乳腺癌抑制基因编码的甘露糖-6-磷酸盐/胰岛素样生长因子2？
5. Domain associations and ligand interactions of the mannose 6-phosphate/insulin-like growth factor II receptor. [D] . Kreiling, Jodi L. 2005

机译：甘露糖6-磷酸/胰岛素样生长因子II受体的域缔合和配体相互作用。
6. Loss of the gene encoding mannose 6-phosphate/insulin-like growth factor II receptor is an early event in liver carcinogenesis [O] . Tomoya Yamada, Angus T. De Souza, Sydney Finkelstein, 1997

机译：甘露糖6-磷酸/胰岛素样生长因子II受体编码基因的丢失是肝癌发生的早期事件
7. Mannose 6-phosphate/insulin-like growth factor II-binding proteins in human serum and urine. Their relation to the mannose 6-phosphate/insulin-like growth factor II receptor. [O] . Causin, C, Waheed, A, Braulke, T, 1988

机译：人血清和尿液中的甘露糖6-磷酸/胰岛素样生长因子II结合蛋白。它们与甘露糖6-磷酸/胰岛素样生长因子II受体的关系。

Loss of the gene encoding mannose 6-phosphate/insulin-like growth factor II receptor is an early event in liver carcinogenesis

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