Loss of the maternal H19 gene induces changes in Igf2 methylation in both cis and trans

T. Forne; J. Oswald; W. Dean

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Loss of the maternal H19 gene induces changes in Igf2 methylation in both cis and trans

机译：母体H19基因的缺失导致顺式和反式Igf2甲基化的改变

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Recent investigations have shown that the maintenance of genomic imprinting of the murine insulin-like growth factor 2 (Igf2) gene involves at least two factors: the DNA (cytosine-5-)-methyltransferase activity, which is re- quired to preserve the paternal specific expression of Igf2, and the H19 gene (lying 90 kb downstream of Igf2 gene), which upon inactivation leads to relaxation of the Igf2 imprint. It is not yet clear how these two factors are related to each other in the process of maintenance of Igf2 imprinting and, in partic- ular, whether the latter is acting through cis elements or whether the H19 RNA itself is involved.

机译：最近的研究表明，维持鼠类胰岛素样生长因子2（Igf2）基因的基因组印迹至少涉及两个因素：DNA（cytosine-5-）-methyltransferase活性，这需要保留父本。特异性表达Igf2和H19基因（位于Igf2基因下游90 kb），这种表达在失活后会导致Igf2印迹的松弛。目前尚不清楚这两个因素在维持Igf2印迹过程中如何相互关联，尤其是后者是否通过顺式分子起作用或是否涉及H19 RNA本身。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第19期|p.10243-10248|共6页
作者
T. Forne; J. Oswald; W. Dean;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Mutation of a Single CTCF Target Site within the H19 Imprinting Control Region Leads to Loss of Igf2 Imprinting and Complex Patterns of De Novo Methylation upon Maternal Inheritance [J] . Vinod Pant, Sreenivasulu Kurukuti, Elena Pugacheva, Molecular and Cellular Biology . 2004,第8期

机译：H19印迹控制区域内单个CTCF目标位点的突变会导致Igf2印迹的丧失和母体遗传后从头甲基化的复杂模式
2. Homocysteine harasses the imprinting expression of IGF2 and H19 by demethylation of differentially methylated region between IGF2/H19 genes [J] . Lijuan Li Jing Xie Meng Zhang and Shuren Wang* Acta Biochimica et Biophysica Sinica . 2009,第6期

机译：同型半胱氨酸通过IGF2 / H19基因之间差异甲基化区域的去甲基化来破坏IGF2和H19的印迹表达
3. Homocysteine harasses the imprinting expression of IGF2 and H19 by demethylation of differentially methylated region between IGF2/H19 genes [J] . Lijuan Li, Jing Xie, Meng Zhang, 生物化学与生物物理学报：英文版 . 2009,第006期

机译：同型半胱氨酸通过IGF2 / H19基因之间的甲基化区域甲基化来破坏IGF2和H19的印迹表达
4. A PHASE FIELD MODEL OF PHOTO-INDUCED TRANS-CIS-TRANS BENDING OF LIQUID CRYSTAL ELASTOMER FILMS [C] . Hongbo Wang, William S. Oates SMASIS2010;ASME conference on smart materials, adaptive structures and intelligent systems . 2011

机译：液晶聚合物薄膜光致反式-CIS-TRANS弯曲的相场模型
5. DNA methylation: Cis, trans, and intergenerational [D] . Taylor, David Harrison. 2016

机译：DNA甲基化：顺式，反式和代际
6. Loss of the maternal H19 gene induces changes in Igf2 methylation in both cis and trans [O] . T. Forné, J. Oswald, W. Dean, 1997

机译：母体H19基因的缺失导致顺式和反式Igf2甲基化的改变
7. Retention of the H19 imprinting and the normal methylation Patterns at the Igf2/H19 differentially-methylated regions in the monoclonal mouse hepatocellular carcinoma cells with loss of the Igf2 imprinting [O] . 石崎, 智章, イシザキ, トモアキ, Ishizaki, Tomoaki 2002

机译：在失去Igf2印迹的单克隆小鼠肝癌细胞中Igf2 / H19差异甲基化区域的H19印迹和正常甲基化模式的保留

Loss of the maternal H19 gene induces changes in Igf2 methylation in both cis and trans

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