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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Oncogenic transformation induced by the Qin protein is correlated with transcriptional repression
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Oncogenic transformation induced by the Qin protein is correlated with transcriptional repression

机译：Qin蛋白诱导的致癌转化与转录抑制相关

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摘要

The retroviral oncogene qin codes for a pro- tein that belongs to the family of the winged helix transcrip- tion factors. The viral Qin protein, v-Qin, differs from its cellular counterpart, c-Qin, by functioning as a stronger transcriptional repressor and a more efficient inducer of tumors. This observation suggests that repression may be important in tumorigenesis. To test this possibility, chimeric proteins were constructed in which the Qin DNA-binding domain was fused to either a strong repressor domain (derived from the Drosophila Engrailed protein) or a strong activator domain (from the herpes simplex virus VP16 protein).
机译：逆转录病毒癌基因qin编码一种蛋白质，该蛋白质属于有翼螺旋转录因子家族。病毒Qin蛋白v-Qin与它的细胞对应蛋白c-Qin不同，它起着更强的转录阻遏物和更有效的肿瘤诱导剂的作用。该观察结果表明，抑制在肿瘤发生中可能是重要的。为了测试这种可能性，构建了嵌合蛋白，其中Qin DNA结合结构域与一个强阻遏物结构域（来自果蝇Engrailed蛋白）或一个强活化剂结构域（来自单纯疱疹病毒VP16蛋白）融合。

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