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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization
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Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization

机译：包含CpG基序的免疫刺激性寡脱氧核苷酸可有效用作肿瘤抗原免疫的免疫佐剂

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摘要

Recent advances in our understanding of the immune response are allowing for the logical design of new approaches to cancer immunization. One area of interest is the development of new immune adjuvants. Immunostimulatory oligodeoxynucleotides containing the CpG motif (CpG ODN) can induce production of a wide variety of cytokines and activate B cells, monocytes, dendritic cells, and NK cells. Using the 38C13 B cell lymphoma model, we assessed whether CpG ODN can function as immune adjuvants in tumor antigen immunization. The idiotype served as the tumor antigen. Select CpG ODN were as effective as complete Freund's adjuvant at inducing an antigen-specific antibody response but were associated with less toxicity.
机译：我们对免疫反应的了解的最新进展允许进行新的癌症免疫方法的逻辑设计。感兴趣的领域之一是开发新的免疫佐剂。包含CpG基序（CpG ODN）的免疫刺激性寡脱氧核苷酸可以诱导多种细胞因子的产生并激活B细胞，单核细胞，树突状细胞和NK细胞。使用38C13 B细胞淋巴瘤模型，我们评估了CpG ODN是否可以在肿瘤抗原免疫中作为免疫佐剂。独特型用作肿瘤抗原。精选的CpG ODN在诱导抗原特异性抗体反应方面与完全弗氏佐剂一样有效，但毒性较小。

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