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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >The orphan nuclear receptor LXRα is positively and negatively regulated by distinct products of mevalonate metabolism
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The orphan nuclear receptor LXRα is positively and negatively regulated by distinct products of mevalonate metabolism

机译：孤儿核受体LXRα受甲羟戊酸代谢不同产物的正负调节

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摘要

LXR is an orphan member of the nuclear hormone receptor superfamily that displays constitutive tran- scriptional activity. We reasoned that this activity may result from the production of an endogenous activator that is a component of intermediary metabolism. The use of metabolic inhibitors revealed that mevalonic acid biosynthesis is re- quired for LXRα activity. Mevalonic acid is a common me- tabolite used by virtually all eukaryotic cells. It serves as a precursor to a large number of important molecules including farnesyl pyrophosphate, geranylgeranyl pyrophosphate, cho- lesterol, and oxysterols.
机译：LXR是核激素受体超家族的孤儿，其表现出组成型转录活性。我们认为这种活性可能是由于内源性激活剂的产生而引起的，该激活剂是中间代谢的组成部分。代谢抑制剂的使用表明，甲氧戊酸的生物合成需要LXRα的活性。甲羟戊酸是几乎所有真核细胞都使用的常见的代谢产物。它用作大量重要分子的前体，包括法呢基焦磷酸酯，香叶基香叶基香叶酯，胆固醇和氧固醇。

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