The affected gene underlying the class K glycosyphosphatidylinositol (GPI) surface protein defect codes for the GPI transamidase

Juanliang Yu; Shanmugam nagarajan; Jansen J.Knez

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The affected gene underlying the class K glycosyphosphatidylinositol (GPI) surface protein defect codes for the GPI transamidase

机译：K类糖基磷脂酰肌醇（GPI）表面蛋白缺陷基础的受影响基因编码GPI转酰胺酶

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The final step in glycosylphosphatidylinosi- tol (GPI) anchoring of cell surface proteins consists of a transamidation reaction in which preassembled GPI donors are substituted for C-terminal signal sequences in nascent polypeptides. In previous studies we described a human K562 cell mutant, termed class K, that accumulates fully assembled GPI units but is unable to transfer them to N-terminally Processed proproteins. In further work we showed that, unlike Wild-type microsomes, microsomes from these cells are unable To support C-terminal interaction of proproteins with the Small nucleophiles hydrazine or hydroxylamine, and that the Cells thus are defective in transamidation.

机译：细胞表面蛋白的糖基磷脂酰肌醇基（GPI）固定的最后一步包括转酰胺基反应，其中预组装的GPI供体被新生多肽中的C端信号序列取代。在先前的研究中，我们描述了一个人类K562细胞突变体，称为K类，该突变体积累了完全组装的GPI单位，但无法将其转移至N末端加工的前蛋白。在进一步的工作中，我们表明，与野生型微粒体不同，来自这些细胞的微粒体无法支持原蛋白与小亲核试剂肼或羟胺的C末端相互作用，因此这些细胞在转酰胺基化方面存在缺陷。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第23期|p.12580-12585|共6页
作者
Juanliang Yu; Shanmugam nagarajan; Jansen J.Knez;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. A defect in glycosylphosphatidylinositol (GPI) transamidase activity in mutant K cells is responsible for their inability to display GPI surface proteins [J] . Rui Chen, Sidney Udenfriend, Gregory M. Prince Proceedings of the National Academy of Sciences of the United States of America . 1996,第6期

机译：突变K细胞中糖基磷脂酰肌醇（GPI）转酰胺酶活性的缺陷是其无法展示GPI表面蛋白的原因
2. Gpi transamidase and gpi anchored proteins: Oncogenes and biomarkers for cancer [J] . GamageD.G., HendricksonT.L. Critical Reviews in Biochemistry and Molecular Biology . 2013,第5期

机译：Gpi转酰胺酶和gpi锚定蛋白：癌症的致癌基因和生物标志物
3. The yopM gene of Yersinia pestis encodes a released protein having homology with the human platelet surface protein GPIb alpha. [J] . K Y Leung, S C Straley Journal of bacteriology . 1989,第9期

机译：鼠疫耶尔森氏菌的yopM基因编码与人血小板表面蛋白GPIbα具有同源性的释放蛋白。
4. New Strategies for Synthesis and Assembly of GPI Anchors and GPI-anchored Proteins: Towards the Unsaturated Synthetic GPI Glycolipids [C] . Vilotijevic I., Varon Silva D., Seeberger P.H. International Carbohydrate Symposium . 2013

机译：GPI锚和GPI锚固蛋白合成和组装的新策略：朝向不饱和合成的GPI糖脂
5. Characterization of Gpi8p, the active site subunit of GPI transamidase, through in vitro techniques. [D] . Meitzler, Jennifer L. 2007

机译：通过体外技术表征Gpi转氨酶的活性位点亚基Gpi8p。
6. The affected gene underlying the class K glycosylphosphatidylinositol (GPI) surface protein defect codes for the GPI transamidase [O] . Jianliang Yu, Shanmugam Nagarajan, Jansen J. Knez, 1997

机译：K类糖基磷脂酰肌醇（GPI）表面蛋白缺陷的潜在受影响基因编码GPI转酰胺酶
7. A defect in glycosylphosphatidylinositol (GPI) transamidase activity in mutant K cells is responsible for their inability to display GPI surface proteins. [O] . Chen, R, Udenfriend, S, Prince, G M, 1996

机译：突变K细胞中糖基磷脂酰肌醇（GPI）转酰胺酶活性的缺陷是造成它们无法展示GPI表面蛋白的原因。

The affected gene underlying the class K glycosyphosphatidylinositol (GPI) surface protein defect codes for the GPI transamidase

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