Molecular mechanism of use-dependent calcium channel block by phenylalkylamines: Role of inactivation

Steffen Hering; Stefan Aczel; Richard L. Kraus

首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Molecular mechanism of use-dependent calcium channel block by phenylalkylamines: Role of inactivation

【24h】

Molecular mechanism of use-dependent calcium channel block by phenylalkylamines: Role of inactivation

机译：苯烷基胺引起的依赖使用的钙通道阻滞的分子机制：失活的作用

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

The role of channel inactivation in the mo- lecular mechanism of calcium (Ca~2+) channel block by phe- nylalkylamines (PAA) was analyzed by designing mutant Ca~2+ channels that carry the high affinity determinants of the PAA receptor site [Hockerman, G. H., Johnson, B. D., Scheuer, T., and Catterall, W. A. (1995) J. Biol. Chem. 270, 22119-22122] but inactivate at different rates. Use-dependent block by PAAs was studied after expressing the mutant Ca~2+ channels in Xenopus oocytes. Substitution of single putative pore- orientated amino acids in segment IIIS6 by alanine (F-1499-A, F-1500-A, F-1510-A, I-1514-A, and F-1515-A) gradually slowed channel inactivation and simultaneously reduced inhibition of barium currents (I_Ba) by (-)D600 upon depolarization by 100 ms steps at 0.1 Hz.

机译：通过设计携带PAA受体位点的高亲和力决定子的突变Ca〜2 +通道，分析了通道失活在苯基（PAA）阻断钙（Ca〜2 +）通道分子机制中的作用。 Hockerman，GH，Johnson，BD，Scheuer，T。，和Catterall，WA（1995）J.Biol.Chem。，1987。化学270，22119-22122]，但以不同的速度失活。在非洲爪蟾卵母细胞中表达突变的Ca〜2 +通道后，研究了PAA的使用依赖性阻断。丙氨酸（F-1499-A，F-1500-A，F-1510-A，I-1514-A和F-1515-A）取代了IIIS6节中单个推定的孔定向氨基酸，从而逐渐减缓了通道失活并且在0.1 Hz时以100 ms的步长去极化时同时降低了（-）D600对钡电流（I_Ba）的抑制。

著录项

来源
《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第24期|p.13323-13328|共6页
作者
Steffen Hering; Stefan Aczel; Richard L. Kraus;
展开▼
作者单位

展开▼
收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词

相似文献

外文文献
中文文献
专利

1. Specific mechanism of use-dependent channel block of calcium-permeable AMPA receptors provides activity-dependent inhibition of glutamatergic neurotransmission. [J] . Zaitsev AV, Kim KK, Fedorova IM, The Journal of Physiology . 2011,第7期

机译：钙可透过的AMPA受体的使用依赖性通道阻滞的特定机制可提供对谷氨酸能神经传递的活性依赖性抑制。
2. Mechanisms of atrial-selective block of Na channels by ranolazine: I. Experimental analysis of the use-dependent block. [J] . Zygmunt AC, Nesterenko VV, Rajamani S, American Journal of Physiology . 2011,第4Parta2期

机译：Ranolazine Na通道心房选择性块的机制：I。使用依赖性块的实验分析。
3. Mechanisms of atrial-selective block of Na channels by ranolazine: I. Experimental analysis of the use-dependent block. [J] . Zygmunt AC, Nesterenko VV, Rajamani S, American Journal of Physiology . 2011,第4Parta2期

机译：Ranolazine Na通道心房选择性块的机制：I。使用依赖性块的实验分析。
4. Non-Antithrombotic Treatment of Acute Coronary Syndromes: Role of Beta-Blockers, Calcium Channel Blockers,and Nitrates [C] . International College of Surgeons . 2002

机译：急性冠状动脉综合征的非抗抗血栓形成：β-封锁剂，钙通道阻滞剂和硝酸盐的作用
5. Mechanisms of calcium-dependent inactivation of L-type calcium channels revealed by fluorescence resonance energy transfer in living cells. [D] . Erickson, Michael Gustaf. 2003

机译：荧光共振能量转移在活细胞中揭示了钙依赖的L型钙通道失活的机制。
6. Molecular mechanism of use-dependent calcium channel block by phenylalkylamines: Role of inactivation [O] . Steffen Hering, Stefan Aczél, Richard L. Kraus, 1997

机译：苯烷基胺的依赖于使用的钙通道阻滞的分子机制：失活的作用
7. Molecular Determinants of High Affinity Phenylalkylamine Block of l-type Calcium Channels in Transmembrane Segment IIIS6 and the Pore Region of the α1Subunit [O] . Gregory H. Hockerman, Barry D. Johnson, Michael R. Abbott, 1997

机译：跨膜段IIIs6中L型钙通道的高亲和力苯基烷基胺块的分子决定因素及α1subUnit的孔区

Molecular mechanism of use-dependent calcium channel block by phenylalkylamines: Role of inactivation

摘要

著录项

相似文献

相关主题

期刊订阅