Inactivation of the α C protein antigen gene, bca, by a novel shuttle/suicide vector results in attenuation of virulence and immunity in group B Streptococcus

Jing Li; Dennis L. Kasper; Frederick M. Ausubel

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Inactivation of the α C protein antigen gene, bca, by a novel shuttle/suicide vector results in attenuation of virulence and immunity in group B Streptococcus

机译：新型穿梭/自杀载体使αC蛋白抗原基因bca失活导致B组链球菌的毒力和免疫力降低

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The C protein of group B Streptococcus (GBS) is a major surface-associated antigen. Although its role in the biology and virulence of GBS has not been defined, it is opsonic and capable of eliciting protective immunity. The α C protein is widely distributed among clinical isolates and is a potential protein carrier and antigen in conjugate vaccines to prevent GBS infections. The structural gene for the α C protein, bca, has been cloned and sequenced. The protein encoded by bca is related to a class of surface-associated proteins of Gram-positive cocci involved in virulence and immunity. To investigate the potential roles of the α C protein, bca null mutants were generated in which the bca gene was replaced with a kanamycin resistance cassette via homologous recombination using a novel shuttle/suicide vector.

机译：B组链球菌（GBS）的C蛋白是一种主要的表面相关抗原。尽管尚未确定其在GBS生物学和毒力中的作用，但它是调理的，能够引起保护性免疫。 αC蛋白在临床分离株中广泛分布，是潜在的蛋白载体和抗原，可预防GBS感染。 αC蛋白bca的结构基因已被克隆和测序。 bca编码的蛋白质与涉及毒力和免疫力的革兰氏阳性球菌的一类表面相关蛋白质有关。为了研究αC蛋白的潜在作用，产生了bca null突变体，其中使用新型穿梭/自杀载体通过同源重组将bca基因替换为卡那霉素抗性盒。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第24期|p.13251-13256|共6页
作者
Jing Li; Dennis L. Kasper; Frederick M. Ausubel;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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6. Inactivation of the α C protein antigen gene bca by a novel shuttle/suicide vector results in attenuation of virulence and immunity in group B Streptococcus [O] . Jing Li, Dennis L. Kasper, Frederick M. Ausubel, 1997

机译：新型穿梭/自杀载体使αC蛋白抗原基因bca失活导致B链球菌群的毒力和免疫力降低
7. Additive Attenuation of Virulence of Streptococcus pneumoniae by Mutation of the Genes Encoding Pneumolysin and Other Putative Pneumococcal Virulence Proteins [O] . Berry, Anne M., Paton, James C. 2000

机译：通过编码肺炎球菌溶血素和其他推定的肺炎球菌毒力蛋白基因的突变，对肺炎链球菌的毒力进行加和衰减。

Inactivation of the α C protein antigen gene, bca, by a novel shuttle/suicide vector results in attenuation of virulence and immunity in group B Streptococcus

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