Identification of a thiamin-dependent synthase in Escherichia coli required for the formation of the 1-deoxy-D-xylulose 5-phosphate precursor to isoprenoids, thiamin, and pyridoxol

Georg A. Sprenger; Ulrich Schorken; Thomas Wiegert

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Identification of a thiamin-dependent synthase in Escherichia coli required for the formation of the 1-deoxy-D-xylulose 5-phosphate precursor to isoprenoids, thiamin, and pyridoxol

机译：鉴定大肠杆菌中硫胺素依赖性合酶，以形成类异戊二烯，硫胺素和吡ido醇的1-脱氧-D-木酮糖5-磷酸酯前体

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In Escherichia coli, 1-deoxy-D-xylulose (or its 5-phosphate, DXP) is the biosynthetic precursor to isopent- enyl diphosphate [Broers, S. T. J. (1994) Dissertation (Eid- gen?ssische Technische Hochschule, Z¨1rich)], thiamin, and pyridoxol [Himmeldirk, K., Kennedy, I. A., Hill, R. E., Sayer, B. G. & Spenser, I. D. (1996) Chem. Commun. 1187-1188]. Here we show that an open reading frame at 9 min on the chromosomal map of E. coli encodes an enzyme (deoxyxylu- lose-5-phosphate synthase, DXP synthase) that catalyzes a thiamin diphosphate-dependent acyloin condensation reac- tion between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield DXP.

机译：在大肠杆菌中，1-脱氧-D-木酮糖（或其5-磷酸酯，DXP）是异戊烯基二磷酸酯的生物合成前体[Broers，STJ（1994）论文（Eidgen？ssische Technische Hochschule，Z¨1rich） ]，硫胺素和吡ido醇[Himmeldirk，K.，Kennedy，IA，Hill，RE，Sayer，BG＆Spenser，ID（1996）Chem。公社1187-1188]。在这里，我们显示了大肠杆菌染色体图谱上第9分钟的开放阅读框编码了一种酶（脱氧木糖5磷酸合酶，DXP合酶），该酶催化硫胺素二磷酸依赖性的C原子之间的酰化缩合反应。丙酮酸和3-磷酸甘油醛的2和3得到DXP。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第24期|p.12857-12862|共6页
作者
Georg A. Sprenger; Ulrich Schorken; Thomas Wiegert;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. The Isogene 1-Deoxy-D-Xylulose 5-Phosphate Synthase 2 Controls Isoprenoid Profiles, Precursor Pathway Allocation, and Densityn of Tomato Trichomes [J] . Michael H. Walter Molecular Plant . 2010,第5期

机译：Isogene 1-脱氧-D-木酮糖5-磷酸合酶2控制番茄类毛虫的类异戊二烯谱，前体通路分配和密度。
2. The isogene 1-deoxy-D-xylulose 5-phosphate synthase 2 controls isoprenoid profiles, precursor pathway allocation, and density of tomato trichomes. [J] . Paetzold H., Garms S., Bartram S., Molecular Plant . 2010,第5期

机译：同基因 1-脱氧-D-木酮糖5-磷酸合酶2 控制类异戊二烯的分布，前体途径分配和番茄毛状体的密度。
3. The Isogene 1-Deoxy-D-Xylulose 5-Phosphate Synthase 2 Controls Isoprenoid Profiles,Precursor Pathway Allocation,and Density of Tomato Trichomes [J] . Heike Paetzold, Michael H.Walter, Stefan Garms, 分子植物（英文版） . 2010,第005期
4. High Efficiency Expression of Trehalose Synthase in Escherichia coli and Its Use in the Production of Trehalose [C] . Hong-Ling Liu, Rui-Ming Wang, Teng-Fei Wang International conference on applied biotechnology . 2018

机译：海藻糖合酶在大肠杆菌中的高效表达及其在海藻糖生产中的应用
5. D-Arabinose 5-phosphate isomerase from Escherichia coli. [D] . Meredith, Timothy C. 2006

机译：来自大肠杆菌的D-阿拉伯糖5-磷酸异构酶。
6. Identification of a thiamin-dependent synthase in Escherichia coli required for the formation of the 1-deoxy-d-xylulose 5-phosphate precursor to isoprenoids thiamin and pyridoxol [O] . Georg A. Sprenger, Ulrich Schörken, Thomas Wiegert, 1997

机译：鉴定大肠杆菌中硫胺素依赖性合酶以形成类异戊二烯硫胺素和啶醇的1-脱氧-d-木酮糖5-磷酸酯前体
7. A mutant pyruvate dehydrogenase E1 subunit allows survival of Escherichia coli strains defective in 1-deoxy-d-xylulose 5-phosphate synthase [O] . Sauret-Güeto Susanna, Urós Eva María, Ibáñez Ester, 2006

机译：突变的丙酮酸脱氢酶E1亚基可使1-脱氧-d-木酮糖5-磷酸合酶有缺陷的大肠杆菌菌株存活

Identification of a thiamin-dependent synthase in Escherichia coli required for the formation of the 1-deoxy-D-xylulose 5-phosphate precursor to isoprenoids, thiamin, and pyridoxol

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