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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >The synthesis of ATP by glycolytic enzymes in the postsynaptic density and the effect of endogenously generated nitric oxide
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The synthesis of ATP by glycolytic enzymes in the postsynaptic density and the effect of endogenously generated nitric oxide

机译：糖酵解酶在突触后密度中的合成ATP和内源性一氧化氮的作用

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摘要

The major contribution of this paper is the finding of a glycolytic source of ATP in the isolated postsynaptic density (PSD). The enzymes involved in the generation of ATP are glyceraldehyde-3-phosphate dehydrogenase (G3PD) and phosphoglycerate kinase (PGK). Lactate dehydrogenase (LDH) is available for the regeneration of NAD+, as well as aldolase for the regeneration of glyceraldehyde-3-phosphate (G3P). The ATP was shown to be used by the PSD Ca~2+/calmodulin-dependent protein kinase and can probably be used by two other PSD kinases, protein kinase A and protein kinase C. We confirmed by immunocytochemistry the presence of G3PD in the PSD and its binding to actin.
机译：本文的主要贡献是在孤立的突触后密度（PSD）中发现了ATP的糖酵解来源。参与ATP产生的酶是3-磷酸甘油醛脱氢酶（G3PD）和磷酸甘油酸激酶（PGK）。乳酸脱氢酶（LDH）可用于再生NAD +，醛缩酶可用于再生3-磷酸甘油醛（G3P）。 ATP已被PSD的Ca〜2 + /钙调蛋白依赖性蛋白激酶所使用，并可能被另外两个PSD激酶（蛋白激酶A和蛋白激酶C）所使用。我们通过免疫细胞化学证实了PSD中存在G3PD及其与肌动蛋白的结合

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