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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Tobacco smoke is a source of toxic reactive glycation products
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Tobacco smoke is a source of toxic reactive glycation products

机译：烟草烟雾是有毒的反应性糖基化产物的来源

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摘要

Smokers have a significantly higher risk for developing coronary and cerebrovascular disease than non- smokers. Advanced glycation end products (AGEs) are reac- tive, cross-linking moieties that form from the reaction of reducing sugars and the amino groups of proteins, lipids, and nucleic acids. AGEs circulate in high concentrations in the plasma of patients with diabetes or renal insufficiency and have been linked to the accelerated vasculopathy seen in patients with these diseases. Because the curing of tobacco takes place under conditions that could lead to the formation of glycation products, we examined whether tobacco and tobacco smoke could generate these reactive species that would increase AGE formation in vivo.
机译：与不吸烟者相比，吸烟者患冠心病和脑血管疾病的风险明显更高。高级糖基化终产物（AGEs）是反应性交联部分，由还原糖与蛋白质，脂质和核酸的氨基反应形成。 AGEs在糖尿病或肾功能不全患者的血浆中以高浓度循环，并与这些疾病患者中见到的加速血管病变有关。因为烟草的固化是在可能导致糖基化产物形成的条件下进行的，所以我们检查了烟草和烟草烟雾是否会产生这些反应性物种，从而增加体内AGE的形成。

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