Interferon-γ impacts at multiple points during the progression of autoimmune diabetes

Bo Wang; Isabelle Andre; Antonio Gonzalez

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Interferon-γ impacts at multiple points during the progression of autoimmune diabetes

机译：干扰素-γ在自身免疫性糖尿病进展过程中的多点影响

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The role of interferon-γ in autoimmune di- abetes was assessed by breeding a null mutation of the interferon-γ receptor α chain into the nonobese diabetic mouse strain, as well as into a simplified T cell receptor transgenic model of diabetes. In contrast to a previous report on abrogation of the interferon-γ gene, mutation of the gene encoding its receptor led to drastic effects on disease in both mouse lines. Nonobese diabetic mice showed a marked inhi- bition of insulitis--both the kinetics and penetrance--and no signs of diabetes; the transgenic model exhibited near-normal insulitis, but this never evolved into diabetes, either sponta- neously or after experimental provocation.

机译：通过将干扰素-γ受体α链的无效突变繁殖到非肥胖糖尿病小鼠品系以及简化的糖尿病T细胞受体转基因模型中，可以评估干扰素-γ在自身免疫性糖尿病中的作用。与先前有关废除干扰素-γ基因的报道相反，编码其受体的基因的突变导致了两种小鼠品系对疾病的严重影响。非肥胖糖尿病小鼠在动力学和渗透方面均表现出明显的胰岛素抵抗，没有糖尿病的征兆。转基因模型表现出接近正常的胰岛炎，但无论是自然发生还是实验性刺激后，都从未演变成糖尿病。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第25期|p.13844-13849|共6页
作者
Bo Wang; Isabelle Andre; Antonio Gonzalez;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Autoimmune Funktionsstörungen der Schilddrüse unter Interferon-ß-1b-Therapie bei Patienten mit Multipler Sklerose [J] . C. Lange-Asschenfeldt, S. Boor, G. J. Kahaly, Der Nervenarzt . 2004,第6期

机译：多发性硬化症患者在干扰素-β-1b治疗下自身免疫性甲状腺功能低下
2. Screening of monogenic autoimmune diabetes among children with type 1 diabetes and multiple autoimmune diseases: is it worth doing? [J] . VeronikaStrakova, LenkaElblova, Matthew B.Johnson, Journal of pediatric endocrinology & metabolism: JPEM . 2019,第10期

机译：筛选1型糖尿病和多种自身免疫疾病的儿童单身自身免疫糖尿病：值得做吗？
3. Latent Autoimmune Diabetes in Adults With Low-Titer GAD Antibodies: Similar Disease Progression With Type 2 Diabetes: A Nationwide, Multicenter Prospective Study (LADA China Study 3). Diabetes Care 2015;38:16-21 [J] . Shah Viral N., Yu Liping Diabetes care . 2015,第3期

机译：成人低滴度GAD抗体的潜在自身免疫性糖尿病：与2型糖尿病相似的疾病进展：一项全国性的多中心前瞻性研究（LADA中国研究3）。糖尿病护理2015; 38：16-21
4. Multi-lag HRV analysis discriminates disease progression of post-infarct people with no diabetes versus diabetes [C] . Karmakar Chandan, Jelinek Herbert F., Khandoker Ahsan, Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2015

机译：多时滞HRV分析可区分无糖尿病和糖尿病的梗死后人群的疾病进展
5. The absence of CD62L (L-selectin) does not inhibit the progression of autoimmune diabetes in nonobese diabetic (NOD) mice. [D] . Friedline, Randall Henry. 2001

机译：在非肥胖糖尿病（NOD）小鼠中，CD62L（L-选择素）的缺乏不会抑制自身免疫性糖尿病的进展。
6. Interferon-γ impacts at multiple points during the progression of autoimmune diabetes [O] . Bo Wang, Isabelle André, Antonio Gonzalez, 1997

机译：干扰素-γ在自身免疫性糖尿病进展过程中的多点影响
7. Prevention of Spontaneous Autoimmune Diabetes in Diabetes-Prone BB Rats by Prophylactic Treatment with Antirat Interferon- Antibody [O] . F. Nicoletti 1997

机译：通过预防性治疗用抗真菌干扰素 - 抗体预防糖尿病 - 易患BB大鼠的自发自身免疫糖尿病

Interferon-γ impacts at multiple points during the progression of autoimmune diabetes

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