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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >The anaphase inhibitor of Saccharomyces cerevisiae Pds1p is a target of the DNA damage checkpoint pathway
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The anaphase inhibitor of Saccharomyces cerevisiae Pds1p is a target of the DNA damage checkpoint pathway

机译：酿酒酵母Pds1p的后期抑制剂是DNA损伤检查点途径的靶标

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摘要

Inhibition of DNA replication and physical DNA damage induce checkpoint responses that arrest cell cycle progression at two different stages. In Saccharomyces cerevisiae, the execution of both checkpoint responses requires the Mec1 and Rad53 proteins. This observation led to the suggestion that these checkpoint responses are mediated through a common signal transduction pathway. However, because the checkpoint-induced arrests occur at different cell cycle stages, the downstream effectors mediating these arrests are likely to be distinct. We have previously shown that the S. cerevisiae protein Pds1p is an anaphase inhibitor and is essential for cell cycle arrest in mitosis in the presence DNA damage.
机译：抑制DNA复制和物理DNA损伤会诱导检查点响应，从而阻止细胞周期在两个不同阶段的进展。在酿酒酵母中，执行两个检查点响应都需要Mec1和Rad53蛋白。该观察结果提示这些检查点反应是通过共同的信号转导途径介导的。但是，由于检查点诱导的阻滞发生在不同的细胞周期阶段，因此介导这些阻滞的下游效应子可能是不同的。先前我们已经表明，酿酒酵母蛋白Pds1p是后期抑制剂，对于存在DNA损伤的有丝分裂中的细胞周期停滞至关重要。

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