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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Superactivation of an immune response triggered by oligomerized T cell epitopes
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Superactivation of an immune response triggered by oligomerized T cell epitopes

机译：寡聚T细胞表位触发的免疫应答的超活化

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摘要

The peptides bound to class II major histo- compatibility complex (MHC) molecules extend out both ends of the peptide binding groove. This structural feature provided the opportunity to design multivalent polypeptide chains that cross- link class II MHC molecules through multiple, repetitive MHC binding sites. By using recombinant techniques, polypeptide oligomers were constructed that consist of up to 32 copies of an HLA-DR1-restricted T cell epitope. The epitope HA306-318, derived from influenza virus hemagglutinin, was connected by 12- to 36-aa long spacer sequences. These oligomers were found to cross-link soluble HLA-DR1 molecules efficiently and, upon binding to the MHC molecules of a monocyte line, to trigger signal transduction indicated by the enhanced expression of some cell surface molecules.
机译：与II类主要组织相容性复合物（MHC）分子结合的肽延伸到肽结合槽的两端。这种结构特征提供了设计多价多肽链的机会，该多价多肽链通过多个重复的MHC结合位点交联了II类MHC分子。通过使用重组技术，构建了多肽寡聚物，该多肽寡聚物由多达32个HLA-DR1限制性T细胞表位组成。源自流感病毒血凝素的表位HA306-318通过12至36aa长的间隔序列连接。发现这些低聚物有效地交联可溶性HLA-DR1分子，并且在与单核细胞系的MHC分子结合后，触发某些细胞表面分子表达增强所指示的信号转导。

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