Phosphorylation-dependent human immunodeficiency virus type 1 infection and nuclear targeting of viral DNA

Alice G. Bukrinskaya; Anuja Ghorpade; Nina K. Heinzinger

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Phosphorylation-dependent human immunodeficiency virus type 1 infection and nuclear targeting of viral DNA

机译：依赖磷酸化的人类1型免疫缺陷病毒感染和病毒DNA的核靶向

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In the replication of human immunodefi- ciency virus type 1 (HIV-1), gag MA (matrix), a major structural protein of the virus, carries out opposing targeting functions. During virus assembly, gag MA is cotranslationally myristoy- lated, a modification required for membrane targeting of gag polyproteins. During virus infection, however, gag MA, by virtue of a nuclear targeting signal at its N terminus, facili- tates the nuclear localization of viral DNA and establishment of the provirus.

机译：在人类1型免疫缺陷病毒（HIV-1）的复制中，gag MA（基质）是该病毒的主要结构蛋白，具有相反的靶向功能。在病毒组装过程中，gag MA被共翻译成十四烷基化，这是对gag多蛋白进行膜靶向所必需的修饰。然而，在病毒感染期间，gag MA凭借其N端的核靶向信号，促进了病毒DNA的核定位和原病毒的建立。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第1期|p.367-371|共5页
作者
Alice G. Bukrinskaya; Anuja Ghorpade; Nina K. Heinzinger;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Prevalence of human papillomavirus infection, distribution of viral types and risk factors in cervical samples from human immunodeficiency virus-positive women attending three human immunodeficiency virus-acquired immune deficiency syndrome reference centres in northeastern Brazil [J] . Martins Albert Eduardo Silva, Lucena-Silva Norma, Garcia Renan Gomes, Memorias do Instituto Oswaldo Cruz . 2014,第6期

机译：来自巴西东北部三个由人类免疫缺陷病毒获得的免疫缺陷综合症参考中心参加的人类免疫缺陷病毒阳性妇女的宫颈样本中的人类乳头瘤病毒感染的流行，病毒类型的分布和危险因素
2. Prevalence of human papillomavirus infection, distribution of viral types and risk factors in cervical samples from human immunodeficiency virus-positive women attending three human immunodeficiency virus-acquired immune deficiency syndrome reference centres in northeastern Brazil [J] . Albert Eduardo Silva Martins, Aureliana Barboza, Magda Maruza, Memórias do Instituto Oswaldo Cruz . 2014,第6期

机译：来自巴西东北部三个由人类免疫缺陷病毒获得的免疫缺陷综合症参考中心参加的人类免疫缺陷病毒阳性妇女的宫颈样本中的人类乳头瘤病毒感染的流行，病毒类型的分布和危险因素
3. Prevalence of human papillomavirus infection, distribution of viral types and risk factors in cervical samples from human immunodeficiency virus-positive women attending three human immunodeficiency virus-acquired immune deficiency syndrome reference centres in northeastern Brazil [J] . Martins Albert Eduardo Silva, Lucena-Silva Norma, Garcia Renan Gomes, Memorias do Instituto Oswaldo Cruz . 2014,第6期

机译：来自巴西东北部三个由人类免疫缺陷病毒获得的免疫缺陷综合症参考中心参加的人类免疫缺陷病毒阳性妇女的宫颈样本中的人类乳头瘤病毒感染的流行，病毒类型的分布和危险因素
4. Simultaneous extraction of human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) RNA with the M1000 apparatus does not impair the measurement of the viral load of both viruses when tested by using the LCx PCR system [C] . T. Bourlet, S. Thamm, S. Pillet, European Congress of Virology . 2004

机译：通过使用LCX PCR系统测试，同时提取人免疫缺陷病毒类型1（HIV-1）和丙型肝炎病毒（HCV）RNA，不会损害两种病毒的病毒载量的测量
5. Longitudinal evaluation of subtype-specific viral load variation in an individual displaying inter-subtype human immunodeficiency virus type-1 superinfection (Immune deficiency). [D] . Srinivasan, Priya. 2003

机译：在显示亚型间人类免疫缺陷病毒1型重叠感染（免疫缺陷）的个体中，对亚型特异性病毒载量变化的纵向评估。
6. Phosphorylation-dependent human immunodeficiency virus type 1 infection and nuclear targeting of viral DNA. [O] . A G Bukrinskaya, A Ghorpade, N K Heinzinger, 1996

机译：依赖磷酸化的人类1型免疫缺陷病毒感染和病毒DNA的核靶向。
7. Phosphorylation-dependent human immunodeficiency virus type 1 infection and nuclear targeting of viral DNA. [O] . Bukrinskaya, A G, Ghorpade, A, Heinzinger, N K, 1996

机译：依赖磷酸化的人类1型免疫缺陷病毒感染和病毒DNA的核靶向。

Phosphorylation-dependent human immunodeficiency virus type 1 infection and nuclear targeting of viral DNA

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