Induction of the WAF1/CIP1 protein and apoptosis in human T-cell leukemia virus type I-transformed lymphocytes after treatment with Adriamycin by using a p53-independent pathway

Ronald B. Gartenhaus; Ping Wang; Peter Hoffmann

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Induction of the WAF1/CIP1 protein and apoptosis in human T-cell leukemia virus type I-transformed lymphocytes after treatment with Adriamycin by using a p53-independent pathway

机译：通过不依赖p53的途径用阿霉素治疗人T细胞白血病病毒I型转化的淋巴细胞中WAF1 / CIP1蛋白的诱导和凋亡

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The WAF1/CIP1 protein has been identified as a downstream mediator of the tumor suppressor p53 in regulating cell cycle progression through a G1-phase check- point. Recent work has implicated the functional status of p53 as a critical determinant in the apoptotic response of certain cell lines to DNA damaging agents. By using human T-cell leukemia virus type I-transformed lymphoid cell lines that differ in their level and function of wild-type p53, we investi- gated the induction of WAF1/CIP1 and apoptosis after ex- posure to Adriamycin, a genotoxic agent.

机译：在通过G1期检查点调节细胞周期进程中，WAF1 / CIP1蛋白被认为是肿瘤抑制因子p53的下游介体。最近的工作表明p53的功能状态是某些细胞系对DNA损伤剂凋亡反应的关键决定因素。通过使用人T细胞白血病病毒I型转化的野生型p53的水平和功能不同的淋巴样细胞系，我们研究了暴露于遗传毒性剂阿霉素后WAF1 / CIP1的诱导和凋亡。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第1期|p.265-268|共4页
作者
Ronald B. Gartenhaus; Ping Wang; Peter Hoffmann;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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机译：核糖蛋白敲低通过上调p53和p21（Waf1 / Cip1）导致人T细胞急性淋巴细胞白血病MOLT-4细胞的细胞周期停滞和凋亡
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5. Subcellular localization of Human T-cell Leukemia Virus Type 1 Tax oncoprotein. [D] . Fryrear, Kimberly Anne. 2008

机译：人T细胞白血病病毒1型税收癌蛋白的亚细胞定位。
6. Induction of the WAF1/CIP1 protein and apoptosis in human T-cell leukemia virus type I-transformed lymphocytes after treatment with adriamycin by using a p53-independent pathway. [O] . R B Gartenhaus, P Wang, P Hoffmann 1996

机译：通过不依赖p53的途径用阿霉素治疗后人T细胞白血病病毒I型转化的淋巴细胞中WAF1 / CIP1蛋白的诱导和凋亡。
7. Induction of the WAF1/CIP1 protein and apoptosis in human T-cell leukemia virus type I-transformed lymphocytes after treatment with adriamycin by using a p53-independent pathway. [O] . Gartenhaus, R B, Wang, P, Hoffmann, P 1996

机译：通过不依赖p53的途径用阿霉素治疗后，人T细胞白血病病毒I型转化的淋巴细胞中WAF1 / CIP1蛋白的诱导和凋亡。
8. Leukemias Associated with Human T-Cell Lymphotropic Virus Type I in a Non-Endemic Region. (Reannouncement with New Availability Information). [R] . Ratner, L., Poiesz, B. J. 1988

机译：白血病与非地方区域的人类T细胞淋巴细胞病毒I型相关。（重新公布新的可用性信息）。

Induction of the WAF1/CIP1 protein and apoptosis in human T-cell leukemia virus type I-transformed lymphocytes after treatment with Adriamycin by using a p53-independent pathway

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