Early p53 alterations in mouse skin carcinogenesis by UVB radiation: Immunohistochemical detection of mutant p53 protein in clusters of preneoplastic epidermal cells

Rob J. W. Berg; Henk J. van Kranen; Heggert G. Rebel

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Early p53 alterations in mouse skin carcinogenesis by UVB radiation: Immunohistochemical detection of mutant p53 protein in clusters of preneoplastic epidermal cells

机译：UVB辐射在小鼠皮肤癌变中的早期p53改变：肿瘤前表皮细胞簇中突变的p53蛋白的免疫组织化学检测

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High levels of the p53 protein are immuno- histochemically detectable in a majority of human nonmela- noma skin cancers and UVB-induced murine skin tumors. These increased protein levels are often associated with mutations in the conserved domains of the p53 gene. To investigate the timing of the p53 alterations in the process of UVB carcinogenesis, we used a well defined murine model (SKH:HR1 hairless mice) in which the time that tumors appear is predictable from the UVB exposures.

机译：在大多数人类非黑素瘤皮肤癌和UVB诱导的鼠类皮肤肿瘤中，免疫组织化学可检测到高水平的p53蛋白。这些增加的蛋白质水平通常与p53基因保守域中的突变有关。为了研究UVB致癌过程中p53改变的时机，我们使用了定义明确的小鼠模型（SKH：HR1无毛小鼠），其中从UVB暴露可以预测肿瘤出现的时间。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第1期|p.274-278|共5页
作者
Rob J. W. Berg; Henk J. van Kranen; Heggert G. Rebel;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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机译：咖啡因对SKH-1小鼠中UVB致癌，凋亡和UVB诱导的p53突变表皮细胞斑块消除的影响
2. Immunohistochemical detection of p53 protein, c-erbB-2 protein, epidermal growth factor receptor protein and proliferating cell nuclear antigen in gastric carcinoma [J] . Jang Woo Ick, Yang Woo Ick, Lee Chong In, Journal of Korean medical science. . 1993,第4期

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5. Investigating the p53-mdm2-ARF signaling circuit: Repression of ARF by the p53 tumor suppressor protein, oncogene activation of ARF, and detection of p53 activity in living cells [D] . Walsh, Christine A. 2006

机译：研究p53-mdm2-ARF信号回路：p53抑癌蛋白抑制ARF，ARF的癌基因激活以及活细胞中p53活性的检测
6. Early p53 alterations in mouse skin carcinogenesis by UVB radiation: immunohistochemical detection of mutant p53 protein in clusters of preneoplastic epidermal cells. [O] . R J Berg, H J van Kranen, H G Rebel, 1996

机译：UVB辐射在小鼠皮肤癌变中的早期p53改变：肿瘤前表皮细胞簇中突变p53蛋白的免疫组织化学检测。
7. Early p53 alterations in mouse skin carcinogenesis by UVB radiation: immunohistochemical detection of mutant p53 protein in clusters of preneoplastic epidermal cells. [O] . Berg, R J, van Kranen, H J, Rebel, H G, 1996

机译：UVB辐射在小鼠皮肤癌变中的早期p53改变：肿瘤前表皮细胞簇中突变p53蛋白的免疫组织化学检测。
8. Susceptibility to Radiation Induced Apoptosis and Senescence in p53 Wild Type and p53 Mutant Breast Tumor Cells [R] . DeMasters, G. 2006

机译：p53野生型和p53突变乳腺癌细胞辐射诱导细胞凋亡和衰老的易感性

Early p53 alterations in mouse skin carcinogenesis by UVB radiation: Immunohistochemical detection of mutant p53 protein in clusters of preneoplastic epidermal cells

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