Prostate-specific membrane antigen is a hydrolase with substrate and pharmacologic characteristics of a neuropeptidase

Ruth E. Carter; Alexis R. Feldman; Joseph T. Coyle

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Prostate-specific membrane antigen is a hydrolase with substrate and pharmacologic characteristics of a neuropeptidase

机译：前列腺特异性膜抗原是一种水解酶，具有神经肽酶的底物和药理特性

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This report demonstrates that the investiga- tional prostatic carcinoma marker known as the prostate- specific membrane antigen (PSM) possesses hydrolytic activi- ity with the substrate and pharmacologic properties of the N-acetylated -linked acidic dipeptidase (NAALADase). NAALADase is a membrane hydrolase that has been charac- terized in the mammalian nervous system on the basis of its catabolism of the neuropeptide N-acetylaspartylglutamate (NAAG) to yield glutamate and N-acetylaspartate and that has been hypothesized to influence glutamatergic signaling processes.

机译：该报告表明，被称为前列腺特异性膜抗原（PSM）的研究性前列腺癌标记物具有与N-乙酰化连接的酸性二肽酶（NAALADase）的底物和药理特性的水解活性。 NAALADase是一种膜水解酶，已基于其对神经肽N-乙酰天冬氨酸谷氨酸（NAAG）的分解代谢而在哺乳动物神经系统中表征，可产生谷氨酸和N-乙酰天冬氨酸，并且已被认为会影响谷氨酸能信号传导过程。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第2期|p.749-753|共5页
作者
Ruth E. Carter; Alexis R. Feldman; Joseph T. Coyle;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Moderate expression of prostate-specific membrane antigen, a tissue differentiation antigen and folate hydrolase, facilitates prostate carcinogenesis. [J] . Yao V, Parwani A, Maier C, Cancer research: The official organ of the American Association for Cancer Research, Inc . 2008,第21期

机译：前列腺特异性膜抗原，组织分化抗原和叶酸水解酶的适度表达促进前列腺癌的发生。
2. Use of methotrexate-based peptide substrates to characterize the substrate specificity of prostate-specific membrane antigen (PSMA). [J] . Mhaka A, Gady AM, Rosen DM, Cancer biology & therapy . 2004,第6期

机译：基于甲氨蝶呤的肽底物用于表征前列腺特异性膜抗原（PSMA）的底物特异性。
3. Synthesis and Biological Evaluation of Substrate-Based Imaging Agents for the Prostate-Specific Membrane Antigen [J] . Youngjoo Byun, Mrudula Pullambhatla, Haofan Wang Macromolecular Research . 2013,第5期

机译：前列腺特异性膜抗原的基于底物的成像剂的合成和生物学评估
4. Long-circulating prostate-specific membrane antigen-targeted NIR phototheranostic agent [C] . Marta Overchuk, Kara M. Harmatys, Martha P. F. Damen, International Photodynamic Association World Congress;Society of Photo-Optical Instrumentation Engineers;International Photodynamic Association . 2019

机译：长循环前列腺特异性膜抗原靶向的近红外光热敏剂
5. Studies on human prostate-specific antigen as a tumor antigen for the immunotherapy of prostate cancer in a mouse model. [D] . Willis, Richard Allen. 2002

机译：人类前列腺特异性抗原作为一种肿瘤抗原的免疫模型在小鼠模型中的研究。
6. Prostate-specific membrane antigen is a hydrolase with substrate and pharmacologic characteristics of a neuropeptidase. [O] . R E Carter, A R Feldman, J T Coyle 1996

机译：前列腺特异性膜抗原是一种水解酶具有神经肽酶的底物和药理特性。
7. Prostate-specific membrane antigen is a hydrolase with substrate and pharmacologic characteristics of a neuropeptidase. [O] . Carter, R E, Feldman, A R, Coyle, J T 1996

机译：前列腺特异性膜抗原是一种水解酶，具有神经肽酶的底物和药理特性。

Prostate-specific membrane antigen is a hydrolase with substrate and pharmacologic characteristics of a neuropeptidase

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