Mutational properties of the primary aflatoxin B_1-DNA adduct

Elisabeth A. Bailey; Rajkumar S. Iyer; Michael P. Stone

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Mutational properties of the primary aflatoxin B_1-DNA adduct

机译：初级黄曲霉毒素B_1-DNA加合物的突变性质

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The mutagenic activity of the major DNA adduct formed by the liver carcinogen aflatoxin B_1 (AFB_1) was investigated in vivo. An oligonucleotide containing a single 8,9-dihydro-8-(N~7-guanyl)-9-hydroxyaflatoxin B_1 (AFB_1-N7- Gua) adduct was inserted into the single-stranded genome of bacteriophage M13. Replication in SOS-induced Escherichia coli yielded a mutation frequency for AFB_1-N7-Gua of 4/100.

机译：在体内研究了由肝致癌物黄曲霉毒素B_1（AFB_1）形成的主要DNA加合物的诱变活性。将包含单个8,9-二氢-8-（N〜7-胍基）-9-羟基黄曲霉毒素B_1（AFB_1-N7-瓜氨酸）加合物的寡核苷酸插入噬菌体M13的单链基因组中。在SOS诱导的大肠杆菌中复制产生的AFB_1-N7-Gua突变频率为4/100。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第4期|p.1535-1539|共5页
作者
Elisabeth A. Bailey; Rajkumar S. Iyer; Michael P. Stone;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Hepatic aflatoxin B1-DNA adducts and TP53 mutations in patients with hepatocellular carcinoma despite low exposure to aflatoxin B1 in southern Japan. [J] . Shirabe K, Toshima T, Taketomi A, Liver international : . 2011,第9期

机译：尽管在日本南部很少接触黄曲霉毒素B1，但肝细胞癌患者的肝黄曲霉毒素B1-DNA加合物和TP53突变。
2. The aflatoxin B1 formamidopyrimidine adduct plays a major role in causing the types of mutations observed in human hepatocellular carcinoma [J] . Maryann E. Smela, Michelle L. Hamm, Paul T. Henderson Proceedings of the National Academy of Sciences of the United States of America . 2002,第10期

机译：黄曲霉毒素B1甲酰嘧啶加合物在引起人类肝细胞癌突变类型中起主要作用
3. The aflatoxin B_1 formamidopyrimidine adduct plays a major role in causing the types of mutations observed in human hepatocellular carcinoma [J] . Maryann E. Smela, Michelle L. Hamm, Paul T. Henderson, Proceedings of the National Academy of Sciences of the United States of America . 2002,第10期

机译：黄曲霉毒素B_1甲酰嘧啶加合物在引起人类肝细胞癌突变类型中起主要作用
4. Aflatoxin-DNA Adducts as Biomarkers of Cancer:Nature, Formation, Kinds of AF—DNA Adducts,Methodology, Effects, and Control [C] . Magda Carvajal Symposia on Mycotoxins and Food Allergens . 2008

机译：黄曲霉毒素-DNA加合物作为癌症的生物标志物：性质，形成，种类的AF-DNA加合物，方法，效果和控制
5. Adduct conformational polymorphism explains adduct mutational complexity based on studies of the major adduct of benzo(a)pyrene in a mutational hotspot. [D] . Jelinsky, Scott A. 1997

机译：加合物构象多态性基于突变热点中苯并（a）py的主要加合物的研究，解释了加合物突变的复杂性。
6. Mutational properties of the primary aflatoxin B1-DNA adduct. [O] . E A Bailey, R S Iyer, M P Stone, 1996

机译：初级黄曲霉毒素B1-DNA加合物的突变性质。
7. Mutational properties of the primary aflatoxin B1-DNA adduct. [O] . Bailey, E A, Iyer, R S, Stone, M P, 1996

机译：初级黄曲霉毒素B1-DNA加合物的突变性质。

Mutational properties of the primary aflatoxin B_1-DNA adduct

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