Protein degradation and increased mRNAs encoding proteins of the ubiquitin-proteasome proteolytic pathway in BC_3H1 myocytes require an interaction between glucocorticoids and acidification

Yuka Isozaki; William E. Mitch; Brian K. England

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Protein degradation and increased mRNAs encoding proteins of the ubiquitin-proteasome proteolytic pathway in BC_3H1 myocytes require an interaction between glucocorticoids and acidification

机译：BC_3H1心肌细胞中蛋白质降解和泛素-蛋白酶体蛋白水解途径蛋白的编码mRNA的增加需要糖皮质激素和酸化之间的相互作用

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In rats and humans, metabolic acidosis stim- ulates protein degradation and glucocorticoids have been implicated in this response. To evaluate the importance of glucocorticoids in stimulating proteolysis, we measured pro- tein degradation in BC_3H1 myocytes cultured in 12/100 serum. Acidification accelerated protein degradation but dexameth- asone did not augment this response.

机译：在大鼠和人类中，代谢性酸中毒会刺激蛋白质降解，而糖皮质激素也参与了这种反应。为了评估糖皮质激素在刺激蛋白水解中的重要性，我们测量了在12/100血清中培养的BC_3H1心肌细胞中蛋白的降解。酸化加速了蛋白质的降解，但地塞米松并未增强这种反应。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第5期|p.1967-1971|共5页
作者
Yuka Isozaki; William E. Mitch; Brian K. England;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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6. Protein degradation and increased mRNAs encoding proteins of the ubiquitin-proteasome proteolytic pathway in BC3H1 myocytes require an interaction between glucocorticoids and acidification. [O] . U Isozaki, W E Mitch, B K England, 1996

机译：BC3H1心肌细胞中的蛋白质降解和编码泛素-蛋白酶体蛋白水解途径蛋白质的增加的mRNAs需要糖皮质激素和酸化之间的相互作用。
7. Protein degradation and increased mRNAs encoding proteins of the ubiquitin-proteasome proteolytic pathway in BC3H1 myocytes require an interaction between glucocorticoids and acidification. [O] . Isozaki, U, Mitch, W E, England, B K, 1996

机译：BC3H1心肌细胞中的蛋白质降解和编码泛素-蛋白酶体蛋白水解途径蛋白质的增加的mRNAs需要糖皮质激素和酸化之间的相互作用。

Protein degradation and increased mRNAs encoding proteins of the ubiquitin-proteasome proteolytic pathway in BC_3H1 myocytes require an interaction between glucocorticoids and acidification

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