Genetic evidence that the RAG1 protein directly participates in V(D)J recombination through substrate recognition

Christopher A. J. Roman; David Baltimore

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Genetic evidence that the RAG1 protein directly participates in V(D)J recombination through substrate recognition

机译：RAG1蛋白通过底物识别直接参与V（D）J重组的遗传证据

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RAG1 protein is essential for the activation of V(D)J recombination in developing lymphocytes (V, vari- able; D, diversity; J, joining). However, it has not been deter- mined whether its role involves substrate recognition and catalysis. A single amino acid substitution mutation in the RAG1 gene has now been identified that renders its activity sensitive to the sequence of the coding region abutting the heptamer site in the recombination signal sequence. These results strongly imply that RAG1 interacts directly with DNA.

机译：RAG1蛋白对于发育中的淋巴细胞中的V（D）J重组激活至关重要（V，可变； D，多样性； J，连接）。但是，尚未确定其作用是否涉及底物识别和催化作用。现在已经鉴定出RAG1基因中的单个氨基酸取代突变，使其活性对重组信号序列中毗邻七聚体位点的编码区序列敏感。这些结果强烈暗示RAG1直接与DNA相互作用。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第6期|p.2333-2338|共6页
作者
Christopher A. J. Roman; David Baltimore;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. V(D)J Recombination: Modulation of RAG1 and RAG2 Cleavage Activity on 12/23 Substrates by Whole Cell Extract and DNA-bending Proteins [J] . Dennis J. Sawchuk, Frances Weis-Garcia, Sohail Malik, The Journal of Experomental Medicine . 1997,第11期

机译：V（D）J重组：通过全细胞提取物和DNA弯曲蛋白对12/23底物上RAG1和RAG2切割活性的调节。
2. Genetic evidence for substrate and periplasmic-binding-protein recognition by the MalF and MalG proteins, cytoplasmic membrane components of the Escherichia coli maltose transport system. [J] . N A Treptow, H A Shuman Journal of bacteriology . 1985,第2期

机译：MALF和马尔格蛋白质的基质和周质结合蛋白质识别的遗传证据，大肠杆菌麦芽糖输送系统的细胞质膜组分。
3. Genetic evidence for substrate and periplasmic-binding-protein recognition by the MalF and MalG proteins, cytoplasmic membrane components of the Escherichia coli maltose transport system. [J] . N A Treptow, H A Shuman Journal of bacteriology . 1985,第2期

机译：MALF和马尔格蛋白质的基质和周质结合蛋白质识别的遗传证据，大肠杆菌麦芽糖输送系统的细胞质膜组分。
4. Generation-recombination defects in AIGaN/GaN HEMT on SiC substrate, evidenced by low frequency noise measurements and SIMS characterization [C] . Jean-Guy Tartarin, Geoffroy Soubercaze-Pun, Jean-Laurent Grondin, International Conference on Noise and Fluctuations . 2007

机译：在SiC衬底上的Aigan / GaN Hemt中的一代 - 重组缺陷，通过低频噪声测量和SIMS表征证明
5. Recruitment of RAG1 and RAG2 to Chromatinized DNA During V(D)J Recombination [D] . Shetty, Keerthi. 2015

机译：V（D）J重组期间，RAG1和RAG2募集到染色质化的DNA
6. Genetic evidence that the RAG1 protein directly participates in V(D)J recombination through substrate recognition. [O] . C A Roman, D Baltimore 1996

机译：RAG1蛋白通过底物识别直接参与V（D）J重组的遗传证据。
7. Genetic evidence that the RAG1 protein directly participates in V(D)J recombination through substrate recognition [O] . Roman Christopher A. J., Baltimore David 1996

机译：RAG1蛋白通过底物识别直接参与V（D）J重组的遗传证据
8. FY05 LDRD Final Report Investigation of AAA+ Protein Machines that Participate in DNA Replication, Recombination, and in Response to DNA Damage LDRD Project Tracking Code: 04-LW-049 [R] . Sawicka, D., de Carvalho-Kavanagh, M. S., Barsky, D., 2006

机译：2005财年LDRD最终报告调查参与DNa复制，重组和DNa损伤的aaa +蛋白质机器LDRD项目跟踪代码：04-LW-049

Genetic evidence that the RAG1 protein directly participates in V(D)J recombination through substrate recognition

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