Identification of a second transmembrane protein tyrosine phosphatase, IA-2β, as an autoantigen in insulin-dependent diabetes mellitus: Precursor of the 37-kDa tryptic fragment

Jia Lu; Qing Li; Hong Xie

首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Identification of a second transmembrane protein tyrosine phosphatase, IA-2β, as an autoantigen in insulin-dependent diabetes mellitus: Precursor of the 37-kDa tryptic fragment

【24h】

Identification of a second transmembrane protein tyrosine phosphatase, IA-2β, as an autoantigen in insulin-dependent diabetes mellitus: Precursor of the 37-kDa tryptic fragment

机译：鉴定第二个跨膜蛋白酪氨酸磷酸酶IA-2β作为胰岛素依赖性糖尿病中的自身抗原：37 kDa胰蛋白酶片段的前体

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

A novel cDNA, IA-2β, was isolated from a mouse neonatal brain library. The predicted protein sequence revealed an extracellular domain, a transmembrane region, and an intracellular domain. The intracellular domain is 376 amino acids long and 74/100 identical to the intracellular domain of IA-2, a major autoantigen in insulin-dependent diabetes mellitus (IDDM). A partial sequence of the extracel- lular domain of IA-2βindicates that it differs substantially (only 26/100 identical) from that of IA-2.

机译：从小鼠新生脑文库中分离出一种新的IA-1βcDNA。预测的蛋白质序列揭示了细胞外结构域，跨膜区和细胞内结构域。细胞内结构域长376个氨基酸，与IA-2的细胞内结构域74/100相同，IA-2是胰岛素依赖性糖尿病（IDDM）中的主要自身抗原。 IA-2β胞外结构域的部分序列表明它与IA-2实质上不同（仅26/100相同）。

著录项

来源
《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第6期|p.2307-2311|共5页
作者
Jia Lu; Qing Li; Hong Xie;
展开▼
作者单位

展开▼
收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词

相似文献

外文文献
专利

1. IA-2, a transmembrane protein of the protein tyrosine phosphatase family, is a major autoantigen in insulin-dependent diabetes mellitus [J] . Michael S. Lan, Clive Wasserfall, Noel K. Maclaren Proceedings of the National Academy of Sciences of the United States of America . 1996,第13期

机译：IA-2是酪氨酸磷酸酶家族的跨膜蛋白，是胰岛素依赖型糖尿病的主要自身抗原
2. THE 37/40-KILODALTON AUTOANTIGEN IN INSULIN-DEPENDENT DIABETES MELLITUS IS THE PUTATIVE TYROSINE PHOSPHATASE IA-2 [J] . Passini N., Genovese S., Appella E., Proceedings of the National Academy of Sciences of the United States of America . 1995,第20期

机译：胰岛素依赖型糖尿病中的37 / 40-KILODALTON自身抗原是酪氨酸磷酸酶IA-2
3. Autoantibodies in insulin-dependent diabetes recognize distinct cytoplasmic domains of the protein tyrosine phosphatase-like IA-2 autoantigen. [J] . Lampasona V, Bearzatto M, Genovese S, The Journal of Immunology: Official Journal of the American Association of Immunologists . 1996,第6期

机译：胰岛素依赖型糖尿病中的自身抗体识别蛋白酪氨酸磷酸酶样IA-2自身抗原的独特胞质结构域。
4. Identification of Significant Protein Diabetes Mellitus Type 2 with Fuzzy C- Means and Topological Analysis [C] . Alif Ahmad Zulfikar, M. Romano Diansyah, Azka Ardhya Rizqa, International Conference on Bioinformatics, Biotechnology, and Biomedical Engineering . 2018

机译：应用模糊C均值和拓扑分析识别2型重要蛋白糖尿病
5. Therapeutic benefits of a soy protein rich diet in the prevention and treatment of nephropathy in young persons with type I, insulin-dependent, diabetes mellitus. [D] . Stephenson, Tammy Jean. 2001

机译：富含大豆蛋白的饮食对预防和治疗I型，胰岛素依赖型糖尿病年轻人的肾病的治疗作用。
6. Identification of a second transmembrane protein tyrosine phosphatase IA-2beta as an autoantigen in insulin-dependent diabetes mellitus: precursor of the 37-kDa tryptic fragment. [O] . J Lu, Q Li, H Xie, 1996

机译：鉴定第二个跨膜蛋白酪氨酸磷酸酶IA-2beta作为胰岛素依赖性糖尿病中的自身抗原：37 kDa胰蛋白酶片段的前体。
7. Identification of a second transmembrane protein tyrosine phosphatase, IA-2beta, as an autoantigen in insulin-dependent diabetes mellitus: precursor of the 37-kDa tryptic fragment. [O] . Lu, J, Li, Q, Xie, H, 1996

机译：鉴定第二个跨膜蛋白酪氨酸磷酸酶IA-2beta作为胰岛素依赖性糖尿病中的自身抗原：37 kDa胰蛋白酶片段的前体。

Identification of a second transmembrane protein tyrosine phosphatase, IA-2β, as an autoantigen in insulin-dependent diabetes mellitus: Precursor of the 37-kDa tryptic fragment

摘要

著录项

相似文献

相关主题

期刊订阅