IA-2, a transmembrane protein of the protein tyrosine phosphatase family, is a major autoantigen in insulin-dependent diabetes mellitus

Michael S. Lan; Clive Wasserfall; Noel K. Maclaren

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IA-2, a transmembrane protein of the protein tyrosine phosphatase family, is a major autoantigen in insulin-dependent diabetes mellitus

机译：IA-2是酪氨酸磷酸酶家族的跨膜蛋白，是胰岛素依赖型糖尿病的主要自身抗原

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IA-2 is a 105,847 Da transmembrane protein that belongs to the protein tyrosine phosphatase family. Immunoperoxidase staining with antibody raised against IA-2 showed that this protein is expressed in human pancreatic islet cells. In this study, we expressed the full-length cDNA clone of IA-2 in a rabbit reticulocyte transcription/translation system and used the recombinant radiolabeled IA-2 protein to detect autoantibodies by immunoprecipitation.

机译：IA-2是一个105,847 Da的跨膜蛋白，属于蛋白酪氨酸磷酸酶家族。用针对IA-2的抗体进行的免疫过氧化物酶染色显示该蛋白在人胰岛细胞中表达。在这项研究中，我们在兔网织红细胞转录/翻译系统中表达了IA-2的全长cDNA克隆，并使用重组放射标记的IA-2蛋白通过免疫沉淀法检测自身抗体。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第13期|p.6367-6370|共4页
作者
Michael S. Lan; Clive Wasserfall; Noel K. Maclaren;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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专利

1. Identification of a second transmembrane protein tyrosine phosphatase, IA-2β, as an autoantigen in insulin-dependent diabetes mellitus: Precursor of the 37-kDa tryptic fragment [J] . Jia Lu, Qing Li, Hong Xie Proceedings of the National Academy of Sciences of the United States of America . 1996,第6期

机译：鉴定第二个跨膜蛋白酪氨酸磷酸酶IA-2β作为胰岛素依赖性糖尿病中的自身抗原：37 kDa胰蛋白酶片段的前体
2. Autoantibodies in insulin-dependent diabetes recognize distinct cytoplasmic domains of the protein tyrosine phosphatase-like IA-2 autoantigen. [J] . Lampasona V, Bearzatto M, Genovese S, The Journal of Immunology: Official Journal of the American Association of Immunologists . 1996,第6期

机译：胰岛素依赖型糖尿病中的自身抗体识别蛋白酪氨酸磷酸酶样IA-2自身抗原的独特胞质结构域。
3. THE 37/40-KILODALTON AUTOANTIGEN IN INSULIN-DEPENDENT DIABETES MELLITUS IS THE PUTATIVE TYROSINE PHOSPHATASE IA-2 [J] . Passini N., Genovese S., Appella E., Proceedings of the National Academy of Sciences of the United States of America . 1995,第20期

机译：胰岛素依赖型糖尿病中的37 / 40-KILODALTON自身抗原是酪氨酸磷酸酶IA-2
4. Modeling and Predicting Protein-Protein Interactions of Type 2 Diabetes Mellitus Using Feedforward Neural Networks [C] . Alif Ahmad Zulfikar, Wisnu Ananta Kusuma International Conference on Advanced Computer Science and information Systems . 2019

机译：使用前馈神经网络建模和预测2型糖尿病的蛋白质-蛋白质相互作用
5. Therapeutic benefits of a soy protein rich diet in the prevention and treatment of nephropathy in young persons with type I, insulin-dependent, diabetes mellitus. [D] . Stephenson, Tammy Jean. 2001

机译：富含大豆蛋白的饮食对预防和治疗I型，胰岛素依赖型糖尿病年轻人的肾病的治疗作用。
6. IA-2 a transmembrane protein of the protein tyrosine phosphatase family is a major autoantigen in insulin-dependent diabetes mellitus. [O] . M S Lan, C Wasserfall, N K Maclaren, 1996

机译：IA-2是蛋白酪氨酸磷酸酶家族的跨膜蛋白是胰岛素依赖型糖尿病的主要自身抗原。
7. IA-2, a transmembrane protein of the protein tyrosine phosphatase family, is a major autoantigen in insulin-dependent diabetes mellitus. [O] . Lan, M S, Wasserfall, C, Maclaren, N K, 1996

机译：IA-2是蛋白酪氨酸磷酸酶家族的跨膜蛋白，是胰岛素依赖型糖尿病的主要自身抗原。

IA-2, a transmembrane protein of the protein tyrosine phosphatase family, is a major autoantigen in insulin-dependent diabetes mellitus

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